Colon-specific oral delivery of vitamin B2 from poly(acrylamide-co-maleic acid) hydrogels: Anin vitro study
| العنوان: | Colon-specific oral delivery of vitamin B2 from poly(acrylamide-co-maleic acid) hydrogels: Anin vitro study |
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| المؤلفون: | S. K. Bajpai, K. G. Kalla, M. Bajpai |
| المصدر: | Journal of Applied Polymer Science. 84:1133-1145 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Chromatography, Polymers and Plastics, Maleic acid, Kinetics, General Chemistry, Polymer, Surfaces, Coatings and Films, chemistry.chemical_compound, chemistry, Acrylamide, Polymer chemistry, Self-healing hydrogels, Materials Chemistry, medicine, Osmotic pressure, Swelling, medicine.symptom, Drug carrier |
| الوصف: | Hydrogels, composed of poly(acrylamide-co-maleic acid) were synthesized and the release of vitamin B2 from these gels was studied as a function of the pH of the external media, the initial amount of the drug loaded, and the crosslinking ratio in the polymer matrix. The gels containing 3.8 mg of the drug per gram gel exhibit almost zero-order release behavior in the external media of pH 7.4 over the time interval of more than their half-life period (t1/2). The amount of the drug loaded into the hydrogel also affected the dynamic release of the encapsulated drug. As expected, the gels showed a complete swelling-dependent mechanism, which was further supported by the similar morphology of the swelling and release profiles of the drug-loaded sample. The hydrophilic nature of the drug riboflavin does not contribute toward the zero-order release dynamics of the hydrogel system. On the other hand, the swelling osmotic pressure developed between the gels and the external phase, due to loading of the drug by equilibration of the gels in the alkaline drug solution, plays an effective role in governing the swelling and release profiles. Finally, the minimum release of the drug in the swelling media of pH 2.0 and the maximum release with zero-order kinetics in the medium of pH 7.4 suggest that the proposed drug-delivery devices have a significant potential to be used as an oral drug-delivery system for colon-specific delivery along the gastrointestinal (GI) tract. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 1133–1145, 2002; DOI 10.1002/app.10402 |
| تدمد: | 1097-4628 0021-8995 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::e5b6b5a4b2b2ef3fe6790f5fb4515913 https://doi.org/10.1002/app.10402 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........e5b6b5a4b2b2ef3fe6790f5fb4515913 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974628 00218995 |
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