Functionalized Bipyrroles and Pyrrolyl-Aminopyrones from Acylethynylpyrroles and Diethyl Aminomalonate
| العنوان: | Functionalized Bipyrroles and Pyrrolyl-Aminopyrones from Acylethynylpyrroles and Diethyl Aminomalonate |
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| المؤلفون: | Boris A. Trofimov, V. V. Kireeva, Maxim D. Gotsko, Igor A. Ushakov, L. N. Sobenina, Ivan V. Saliy |
| المصدر: | Synthesis. 54:1134-1144 |
| بيانات النشر: | Georg Thieme Verlag KG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Diethyl aminomalonate hydrochloride, Nitrogen atom, Chemistry, Yield (chemistry), Organic Chemistry, Medicinal chemistry, Catalysis, Diethyl aminomalonate |
| الوصف: | An efficient method for the synthesis of 1H,1′H-2,3′-bipyrroles (up to 72% yield) by the cyclocondensation of easily available 2-(acylethynyl)pyrroles with diethyl aminomalonate hydrochloride has been developed. The reaction proceeds under reflux in MeCN (6 h) in the presence of Cs2CO3. Under the same conditions, 2-(acylethynyl)pyrroles with bulky (benzyl and octyl) substituents at nitrogen atom react with diethyl aminomalonate to afford 1H,2′H-2,3′-bipyrroles and pyrrolyl-aminopyrones. |
| تدمد: | 1437-210X 0039-7881 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f029d7ea3d8a9acbdc6ad389045ff077 https://doi.org/10.1055/a-1681-4164 |
| رقم الأكسشن: | edsair.doi...........f029d7ea3d8a9acbdc6ad389045ff077 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437210X 00397881 |
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