Synthesis of magnetic core-branched Au shell nanostructures and their application in cancer-related miRNA detection via SERS
| العنوان: | Synthesis of magnetic core-branched Au shell nanostructures and their application in cancer-related miRNA detection via SERS |
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| المؤلفون: | Lianhui Wang, Youzhi Sun, Yanjun Yang, Bing Liu, Ye Chen, Chunyuan Song, Dan Zhu, Boyue Yang, Jie Chao, Xinyu Jiang, Qiaowei Zhang |
| المصدر: | Science China Materials. 60:1129-1144 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Detection limit, Nanostructure, Materials science, Shell (structure), Nanoparticle, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Magnetic field, Magnetic core, Magnetic nanoparticles, General Materials Science, 0210 nano-technology, Superparamagnetism |
| الوصف: | Magnetic core gold shell nanostructures which integrate both SERS activity and superparamagnetism are widely utilized in SERS-based detection as SERS substrates, sample separation and preconcentration operators, as well as external magnetic field controlled directional carrier. However, most of the reported gold shells coated on the magnetic cores had smooth surfaces rather than branched nanostructures with enhanced SERS activity. Here, a novel type of Fe3O4-Au core-shell nanoparticles with branched gold shell was prepared by a seed-mediated method together with the shape induction agent AgNO3, and their growth process and mechanism, properties, as well as morphologically controlled synthesis were also investigated. The branched gold coated magnetic nanoparticles (B-GMNPs) with improved SERS performance were further utilized to build superparamagnetic and SERS-active capturers by assembling tetrahedral DNA onto their surfaces for sandwich-structured detection of cancer-related biomarker miRNA-21. The experimental results indicate that highly sensitive and specific detections can be obtained by the proposed SERS sensing system including B-GMNPs and tetrahedral DNA, and the limit of detection (LOD) of miRNA-21 in serum is 623 amol L−1. These B-GMNPs can be used as good SERS substrates with the functions of external magnetic field controlled sample separation and directional enrichment for effective SERS-based biochemical sensing and detections. |
| تدمد: | 2199-4501 2095-8226 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f50464acbb0be5ab4bb43617b7f644d8 https://doi.org/10.1007/s40843-017-9022-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........f50464acbb0be5ab4bb43617b7f644d8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 21994501 20958226 |
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