Genetic engineering of endotheiial cells
| العنوان: | Genetic engineering of endotheiial cells |
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| المؤلفون: | Josef Anrather, Christine Brostjan, Christopher Wrighton, Hans Winkler, Andrew McShea, Fritz H. Bach |
| المصدر: | Xenotransplantation. 2:197-200 |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Genetics, Transplantation, Xenotransplantation, medicine.medical_treatment, Transgene, Immunology, medicine, Biology, Cell activation, Phenotype, Gene, Cell biology |
| الوصف: | Endotheiial cell activation is a major obstacle to successful xenotransplantation. The activated phenotype is largely based on the transcriptional induction of a number of genes and their products. Due to the large number of new gene products in activated endotheiial cells, it is not feasible to target each of them individually for therapeutic intervention. A common factor important for the induction of many, if not all, genes induced upon endotheiial cell activation if NF-KB. It is thus a reasonable target for inhibition if one is to attempt to inhibit endotheiial cell activation genetically. Donor animals for xenotransplantation are amenable to genetic manipulation and we believe that transgenic animals carrying several transgenes will be the standard of future experimental and clinical xenotransplantation. |
| تدمد: | 1399-3089 0908-665X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f650ad4b1113e0e93fff232f4bf8aa4e https://doi.org/10.1111/j.1399-3089.1995.tb00094.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........f650ad4b1113e0e93fff232f4bf8aa4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993089 0908665X |
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