Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy
| العنوان: | Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy |
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| المؤلفون: | Jinjun Shao, Xiaochen Dong, Dongliang Yang, Han Cai, Ai-Hong Jiao, Peng Chen, Qing Shen, Xinyu Qu, Ying Hong, Xu Sun |
| المصدر: | Rare Metals. 41:56-66 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Absorption (pharmacology), Materials science, technology, industry, and agriculture, Metals and Alloys, Nanoparticle, Photothermal therapy, Condensed Matter Physics, Photochemistry, Fluorescence, Photoinduced electron transfer, chemistry.chemical_compound, chemistry, Intramolecular force, Amphiphile, Materials Chemistry, Physical and Theoretical Chemistry, Dimethylamine |
| الوصف: | To develop smart and efficient near-infrared (NIR) organic dyes for photothermal cancer therapy is of great challenge. Herein, a pH-sensitive NIR dye BTN with donor–acceptor–donor scaffold has been synthesized. Two periphery electron-donating dimethylamine groups in BTN can not only promote the intramolecular photoinduced electron transfer (PET), but also bind protons to transform into electron-deficient ammonium cation for enhanced intramolecular charge transfer (ICT) under acidic circumstance. Through enveloping with amphiphilic polymeric 1,2-distearoyl-ras-glycerol-3-phosphatidyl ethanolamine-N-polyethyleneglycol-2000 (DSPE-mPEG2000), BTN nanoparticles (NPs) were fabricated with robust NIR absorption covering 600–900 nm, excellent photothermal conversion efficiency (43.2%), and good photostability. Additionally, BTN NPs can selectively target lysosomes. Through tailing intravenous injection into tumor-bearing nude mice, BTN NPs demonstrate outstanding photoacoustic/photothermal/fluorescence imaging-guided photothermal therapy for tumor ablation. |
| تدمد: | 1867-7185 1001-0521 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::f78da0de6e865eb6945844aa7b156ca8 https://doi.org/10.1007/s12598-021-01795-0 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........f78da0de6e865eb6945844aa7b156ca8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18677185 10010521 |
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