Delivering 2-Aryl Benzoxazoles through Metal-Free and Redox-Neutral De-CF3 Process
| العنوان: | Delivering 2-Aryl Benzoxazoles through Metal-Free and Redox-Neutral De-CF3 Process |
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| المؤلفون: | Yong-De Zhao, Xinxin Qiao, Heng-Ying Xiong, Guangwu Zhang, Zhanwei Bu, Mingru Rao |
| المصدر: | The Journal of Organic Chemistry. 86:13548-13558 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, Benzothiazole, Metal free, Aryl, Organic Chemistry, Aromatization, Substrate (chemistry), Benzoxazole, Cleavage (embryo), Combinatorial chemistry, Redox |
| الوصف: | An unexpected cleavage of the Csp3-CF3 bond of CF3-hydrobenzoxazoles has been disclosed, affording a range of 2-aryl benzoxazoles under metal-free and redox-neutral conditions. This transformation has demonstrated broad substrate scope and good compatibility of functional groups. 2-Aryl benzothiazole and 2-aryl benzoimidazole could be smoothly assembled in the same manner. On the basis of preliminary mechanistic studies, base initiated and aromatization driven β-carbon elimination was considered to be the key step for the formation of 2. This reaction offers an alternative, facile, and sustainable route to access important 2-aryl benzoxazole motifs. |
| تدمد: | 1520-6904 0022-3263 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::fd32bb4f6b34a960cd5ab5232ab58a7a https://doi.org/10.1021/acs.joc.1c01619 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........fd32bb4f6b34a960cd5ab5232ab58a7a |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206904 00223263 |
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