Recent advances in the diagnosis, differential diagnostics, and salient features of clinical relevance are concisely presented in this chapter. The role of fine needle aspiration and the limitations of this procedure in presurgical management of patients with these tumors are emphasized in communicating findings to clinicians. Similarly, the utilization of lineage-associated markers in the diagnosis and differential diagnosis of salivary and non-salivary tumors is tailored to emphasize context association. In this chapter, verified and consistent molecular and genetic findings are presented for familiarity and for their potential clinical and therapeutic implications. Emphasis on the future integration of these findings in current diagnosis and management remains to be validated.