Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
| العنوان: | Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses |
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| المؤلفون: | Franjo Marković, D Rukavina, Martina Lojkić, Juraj Šavorić, Predrag Kočila, Marko Samardžija, Hrvoje Valpotić, Ivica Valpotić, Z Vidas, Nino Maćešić, I Žura Žaja, M Gerenčer, Denis Leiner, A Kaštelan, M Lazarević, Ivan Butković, A Milovanović, Dražen Đuričić |
| المصدر: | Veterinary quarterly Volume 40 Issue 1 Veterinary Quarterly Veterinary Quarterly, Vol 40, Iss 1, Pp 353-383 (2020) The Veterinary Quarterly article-version (VoR) Version of Record |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Infertility, Reproductive immunology, 040301 veterinary sciences, reproductive immunology, Veterinary medicine, transplantation immun- ology, viviparous mammals, semiallogeneic foetus, allogeneic gamete, immunotrophism, CD45, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Immunology, transplantation immun ology, Review, Biology, Bioinformatics, 0403 veterinary science, Immune system, SF600-1100, medicine, Organism, Immune mechanisms, Pregnancy, General Veterinary, 0402 animal and dairy science, 04 agricultural and veterinary sciences, cd45, medicine.disease, 040201 dairy & animal science, Embryo transfer, 3. Good health, Transplantation, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Imunologija, transplantation immunology |
| الوصف: | Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals. Link to the corrected article: [https://vet-erinar.vet.bg.ac.rs/handle/123456789/2052] |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0165-2176 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016277188f1f216eee1ad1fa206f7366 https://repository.medri.uniri.hr/islandora/object/medri:6179 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....016277188f1f216eee1ad1fa206f7366 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 01652176 |
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