Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections
| العنوان: | Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections |
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| المؤلفون: | Joseph Verdi, Ana Rodriguez, Juan Rivera-Correa, Julian Sherman, Jeremy M Sternberg, Jayne Raper |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009814 (2021) PLoS Neglected Tropical Diseases |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, B Cells, Erythrocytes, Physiology, RC955-962, Autoimmunity, medicine.disease_cause, Biochemistry, White Blood Cells, Mice, Medical Conditions, Animal Cells, Immune Physiology, Red Blood Cells, Arctic medicine. Tropical medicine, Medicine and Health Sciences, African trypanosomiasis, Protozoans, Immune System Proteins, biology, Eukaryota, Anemia, Hematology, Middle Aged, Infectious Diseases, Female, Cellular Types, Antibody, Public aspects of medicine, RA1-1270, Research Article, Adult, Trypanosoma, Adolescent, Immune Cells, Immunology, Trypanosoma brucei brucei, Phosphatidylserines, Trypanosoma brucei, Antibodies, Young Adult, parasitic diseases, Parasitic Diseases, Trypanosoma Brucei, medicine, Animals, Humans, Antibody-Producing Cells, Trypanosoma cruzi, Autoantibodies, Blood Cells, business.industry, Organisms, Public Health, Environmental and Occupational Health, Autoantibody, Biology and Life Sciences, Proteins, Cell Biology, biology.organism_classification, medicine.disease, Parasitic Protozoans, Trypanosomiasis, African, biology.protein, business, Trypanosoma Brucei Gambiense |
| الوصف: | Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and human patients infected with malaria parasites, atypical B-cells promote anemia through the secretion of autoimmune anti-phosphatidylserine (anti-PS) antibodies that bind to uninfected erythrocytes and facilitate their clearance. Using mouse models of two trypanosome infections, Trypanosoma brucei and Trypanosoma cruzi, we assessed levels of autoantibodies and anemia. Our results indicate that acute T. brucei infection, but not T. cruzi, leads to early increased levels of plasma autoantibodies against different auto antigens tested (PS, DNA and erythrocyte lysate) and expansion of atypical B cells (ABCs) that secrete these autoantibodies. In vitro studies confirmed that a lysate of T. brucei, but not T. cruzi, could directly promote the expansion of these ABCs. PS exposure on erythrocyte plasma membrane seems to be an important contributor to anemia by delaying erythrocyte recovery since treatment with an agent that prevents binding to it (Annexin V) ameliorated anemia in T. brucei-infected mice. Analysis of the plasma of patients with human African trypanosomiasis (HAT) revealed high levels of anti-PS antibodies that correlated with anemia. Altogether these results suggest a relation between autoimmunity against PS and anemia in both mice and patients infected with T. brucei. Author summary African trypanosomes are relevant pathogens and a cause of great morbidity and economic burden in endemic countries. Anemia during infection by African Trypanosomes is one of the most common pathologies associated with the disease, but the mechanisms leading to it are poorly understood. Here, we report evidence of autoimmunity, particularly autoantibodies against the lipid phosphatidylserine that are secreted by autoimmune/atypical B-cells, in Trypanosoma brucei infected mice and that are also found in Human African Trypanosomiasis patients and correlate with levels of anemia. These findings point to a relation between autoimmunity and anemia during infection with African Trypanosomes, possibly through the secretion of autoantibodies against phosphatidylserine. |
| اللغة: | English |
| تدمد: | 1935-2735 1935-2727 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01768d5ca6eb22ffa013f11a20e144f3 https://doaj.org/article/75eca697b21141c1ba78895455e9cb51 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....01768d5ca6eb22ffa013f11a20e144f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19352735 19352727 |
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