أعرض في EDS

More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

التفاصيل البيبلوغرافية
العنوان: More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder
المؤلفون: Ming Chuan Hu, Yun Hsuan Chang, Sheng Yu Lee, Shiou Lan Chen, I. Hui Lee, Po See Chen, Chia Ling Li, Shih Hsien Lin, Jau-Shyong Hong, Yen Kuang Yang, Tzu Yun Wang, Chun Hsien Chu, Liang-Jen Wang, Kao Chin Chen, Ru Band Lu, San Yuan Huang, Nian-Sheng Tzeng, Shih Heng Chen
المصدر: Psychoneuroendocrinology. 85:42-48
بيانات النشر: Elsevier BV, 2017.
سنة النشر: 2017
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Substance-Related Disorders, Endocrinology, Diabetes and Metabolism, Inflammation, Comorbidity, behavioral disciplines and activities, Proinflammatory cytokine, Transforming Growth Factor beta1, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Neurotrophic factors, Internal medicine, mental disorders, medicine, Humans, health care economics and organizations, Biological Psychiatry, Brain-derived neurotrophic factor, Tumor Necrosis Factor-alpha, Endocrine and Autonomic Systems, Brain-Derived Neurotrophic Factor, Antisocial personality disorder, Confounding, Opioid use disorder, Antisocial Personality Disorder, Middle Aged, Opioid-Related Disorders, medicine.disease, humanities, Interleukin-10, Psychiatry and Mental health, C-Reactive Protein, 030104 developmental biology, behavior and behavior mechanisms, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology
الوصف: Antisocial personality disorder (ASPD) is highly comorbid with substance use disorders (SUDs). We hypothesize that chronic neuroinflammation and the loss of neurotrophic factors prompts the pathogenesis of both disorders. We used ELISA to measure plasma levels of proinflammatory (tumor necrosis factor-α [TNF-α], C-reactive protein [CRP]) and anti-inflammatory factors (transforming growth factor-β1 [TGF-β1] and interleukin-10 [IL-10]), and brain-derived neurotrophic factor (BDNF) in male patients with ASPD (n=74), SUDs (n=168), ASPD comorbid with SUDs (ASPD+SUDs) (n=438), and Healthy Controls (HCs) (n=81). A multivariate analysis of covariance (MANCOVA) controlled for possible confounders was used to compare cytokines and BDNF levels between groups. The results of MANCOVA adjusted for age showed a significant (p
تدمد: 0306-4530
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c308ea7cfdb09b8ac45b402f4fd150
https://doi.org/10.1016/j.psyneuen.2017.08.006
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....01c308ea7cfdb09b8ac45b402f4fd150
قاعدة البيانات: OpenAIRE
الوصف
تدمد:03064530