The PI3K/Akt Cascade Is Involved in the Antidiabetic Effect of Compound GSB-214, a Low-Molecular-Weight BDNF Mimetic
| العنوان: | The PI3K/Akt Cascade Is Involved in the Antidiabetic Effect of Compound GSB-214, a Low-Molecular-Weight BDNF Mimetic |
|---|---|
| المؤلفون: | S. B. Seredenin, R. U. Ostrovskaya, Tatiana A Gudasheva, S. S. Yagubova |
| المصدر: | Bulletin of Experimental Biology and Medicine. 169:771-774 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Male, 0301 basic medicine, C57BL/6, Morpholines, Pharmacology, Streptozocin, General Biochemistry, Genetics and Molecular Biology, Diabetes Mellitus, Experimental, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Weight Loss, medicine, Animals, Hypoglycemic Agents, Protein kinase B, PI3K/AKT/mTOR pathway, biology, Chemistry, Akt/PKB signaling pathway, Brain-Derived Neurotrophic Factor, General Medicine, biology.organism_classification, Streptozotocin, medicine.disease, Mice, Inbred C57BL, Molecular Weight, 030104 developmental biology, Gene Expression Regulation, Chromones, Peptidomimetics, Proto-Oncogene Proteins c-akt, 030217 neurology & neurosurgery, Signal Transduction, medicine.drug |
| الوصف: | In our previous studies on the streptozotocin model of diabetes we hypothesized that activation of the PI3K/Akt signaling pathway is essential for the realization of the antidiabetic effect of low-molecular-weight NGF and BDNF mimetics. Here we analyze the effect of a specific PI3K/Akt pathway inhibitor (LY 294002) on the antidiabetic effect of the BDNF loop 1 mimetic GSB-214. The experiments on C57BL/6 mice with streptozotocin-induced diabetes showed that GSB-214 attenuated the hyperglycemic effect of streptozotocin and prevented weight loss typical of diabetes, while LY 294002 eliminated these effects of GSB-214. These findings clearly demonstrate the involvement of PI3K/Akt pathway in the implementation of the effects of this low-molecular-weight BDNF mimetic. |
| تدمد: | 1573-8221 0007-4888 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0238141fb18ca72e9d02181fac435fd7 https://doi.org/10.1007/s10517-020-04975-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0238141fb18ca72e9d02181fac435fd7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15738221 00074888 |
|---|