The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways
| العنوان: | The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways |
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| المؤلفون: | Jianxing He, Youfei Qi, Shunwu Chang, Zhan-Xiang Xiao, Jie Yue |
| المصدر: | Oncology Letters. |
| بيانات النشر: | Spandidos Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Cancer Research, Oxidase test, Reactive oxygen species, NADPH oxidase, biology, Articles, 030204 cardiovascular system & hematology, Pharmacology, medicine.disease_cause, Angiotensin II, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oncology, chemistry, Puerarin, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, medicine, Signal transduction, Oxidative stress |
| الوصف: | Puerarin, an active ingredient of Pueraria lobata, has a range of pharmacological effects and excellent pharmacodynamic properties. In the present study, the effect of puerarin on angiotensin II-induced aortic aneurysm formation and the potential underlying molecular mechanisms were examined. The results revealed that puerarin significantly suppressed the viability, and induced the apoptosis, of aneurysm-inducing cells in a time- and dose-dependent manner. Furthermore, treatment with puerarin significantly suppressed the production of reactive oxygen species (ROS) and the expression of matrix metalloproteinase-2 (MMP-2) protein in aneurysm cells. Puerarin treatment significantly increased caspase-9 and −3 activity, induced the protein expression of phosphorylated (p)-Jun and inhibited the protein expression of activator protein 1 (AP-1) in aneurysm cells. It was also demonstrated that Puerarin significantly suppressed the reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase activity in aneurysm cells. Therefore, it was demonstrated that puerarin on suppressed the cell growth of angiotensin II-induced aortic aneurysm formation by affecting the rate of apoptosis, the generation of ROS, MMP-2, AP-1 and p-Jun protein expression and NADPH oxidase. |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d21e2aaf8915a42def08ced2d7f9ad https://doi.org/10.3892/ol.2018.9021 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....04d21e2aaf8915a42def08ced2d7f9ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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