Antibody responses induced by immunization of inbred mice susceptible and resistant to African trypanosomes
| العنوان: | Antibody responses induced by immunization of inbred mice susceptible and resistant to African trypanosomes |
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| المؤلفون: | T W Pearson, L A Mitchell |
| المصدر: | Infection and Immunity. 40:894-902 |
| بيانات النشر: | American Society for Microbiology, 1983. |
| سنة النشر: | 1983 |
| مصطلحات موضوعية: | Mice, Inbred A, Trypanosoma brucei gambiense, Immunology, chemical and pharmacologic phenomena, Microbiology, Immunoglobulin G, Mice, Immune system, Antigen, Animals, Glycoproteins, biology, Membrane Proteins, Variable surface glycoprotein, Virology, Immunity, Innate, Mice, Inbred C57BL, Trypanosomiasis, African, Infectious Diseases, Immunoglobulin M, Immunization, Antibody Formation, biology.protein, Parasitology, Antibody, Variant Surface Glycoproteins, Trypanosoma, Keyhole limpet hemocyanin, Research Article |
| الوصف: | We tested the ability of inbred mice that were either susceptible (strain A/J) or resistant (strain C57BL/6 and A/J X C57BL/6 hybrids) to African trypanosomes to produce specific antibodies to trypanosome antigens in the absence of living parasites. This experiment was carried out to eliminate the influence of trypanosome growth or metabolism on immune responsiveness. Mice were immunized with keyhole limpet hemocyanin or solubilized Trypanosoma brucei gambiense, and serum antibodies were measured in solid-phase radioimmunometric assays after primary and challenge injections. Both susceptible and resistant mice showed increases in keyhole limpet hemocyanin-specific or trypanosome-specific immunoglobulin M and immunoglobulin G after immunization. When immunized with trypanosome antigens, resistant mice made qualitatively and quantitatively superior specific immunoglobulin M responses, particularly to the trypanosome major variable surface glycoprotein. Susceptible A/J mice produced good specific antibody responses, although these were predominantly of the immunoglobulin G isotypes. These results show that A/J and C57BL/6 mice respond differentially in terms of immunoglobulin isotype and repertoire in response to injected antigens. The possibility that this differential antibody response influences susceptibility to African trypanosomes is discussed. |
| تدمد: | 1098-5522 0019-9567 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090fa47b72942b054b905fae1a3bd284 https://doi.org/10.1128/iai.40.3.894-902.1983 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....090fa47b72942b054b905fae1a3bd284 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985522 00199567 |
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