Recurrence after resection with curative intent for distal cholangiocarcinoma
| العنوان: | Recurrence after resection with curative intent for distal cholangiocarcinoma |
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| المؤلفون: | K Komaya, T Ebata, K Shirai, S Ohira, N Morofuji, A Akutagawa, R Yamaguchi, M Nagino, T Aoba, Y Kaneoka, T Arai, Y Shimizu, Y Fukami, E Sakamoto, H Miyake, D Takara, Y Tojima, T Kawahara, S Mizuno, N Matsumoto, S Ota, M Takano, H Yamamoto, M Inoue, Y Asaba, T Watanabe, M Hashimoto, S Kawai, K Ikuta, H Matsubara, S Kondo |
| المصدر: | British Journal of Surgery. 104:426-433 |
| بيانات النشر: | Oxford University Press (OUP), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Perineural invasion, 030230 surgery, Resection, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Humans, Medicine, Neoplasm Invasiveness, Neoplasm Metastasis, Aged, Retrospective Studies, Aged, 80 and over, Curative intent, business.industry, Proportional hazards model, Incidence (epidemiology), Retrospective cohort study, Middle Aged, Pancreaticoduodenectomy, Surgery, Treatment Outcome, medicine.anatomical_structure, Bile Duct Neoplasms, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, Neoplasm Recurrence, Local, business, Pancreas |
| الوصف: | Background Few studies have been conducted on patterns of recurrence after resection for distal cholangiocarcinoma (DCC). The aim of this study was to investigate the incidence and pattern of recurrence after resection of DCC, and to evaluate prognostic factors for time to recurrence and recurrence-free survival (RFS). Methods Patients who underwent pancreatoduodenectomy with curative intent for DCC between 2001 and 2010 at one of 30 hospitals in Japan were reviewed retrospectively, with special attention to recurrence patterns. The Cox proportional hazards model was used for multivariable analysis. Results In the study interval, 389 patients underwent pancreatoduodenectomy for DCC with R0/M0 status. Recurrence developed in 213 patients (54·8 per cent). The estimated cumulative probability of recurrence was 54·3 per cent at 5 years. An initial locoregional recurrence occurred in 55 patients (14·1 per cent) and initial distant recurrence in 168 (43·2 per cent), most commonly in the liver. Isolated initial locoregional recurrence occurred in 45 patients (11·6 per cent). Independent prognostic factors for time to recurrence and RFS were perineural invasion (P = 0·001 and P = 0·009 respectively), pancreatic invasion (both P < 0·001) and lymph node metastasis (both P < 0·001). RFS worsened as the number of risk factors increased: the 5-year RFS rate was 70·6 per cent for patients without any risk factors, 50·3 per cent for patients with one factor, 31·8 per cent for those with two factors, and 13·4 per cent when three factors were present. Conclusion More than half of patients with DCC experienced recurrence after R0 resection, usually within 5 years. Perineural invasion, pancreatic invasion and positive nodal involvement are risk factors for recurrence. |
| تدمد: | 1365-2168 0007-1323 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09583bc2e9da85859200f6a726c5a9c6 https://doi.org/10.1002/bjs.10452 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....09583bc2e9da85859200f6a726c5a9c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652168 00071323 |
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