A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning inXenopus
| العنوان: | A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning inXenopus |
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| المؤلفون: | Christof Niehrs, Clemens Kiecker |
| المصدر: | Development. 128:4189-4201 |
| بيانات النشر: | The Company of Biologists, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | medicine.medical_specialty, Embryo, Nonmammalian, animal structures, Xenopus, Nerve Tissue Proteins, Ectoderm, Xenopus Proteins, Biology, Nervous System, Wnt3 Protein, Proto-Oncogene Proteins, Internal medicine, medicine, Animals, Molecular Biology, Early Growth Response Protein 2, beta Catenin, Body Patterning, Homeodomain Proteins, Otx Transcription Factors, Neuroectoderm, Wnt signaling pathway, Gene Expression Regulation, Developmental, Proteins, Embryo, Zebrafish Proteins, biology.organism_classification, Cell biology, DNA-Binding Proteins, Wnt Proteins, Gastrulation, Cytoskeletal Proteins, medicine.anatomical_structure, Endocrinology, embryonic structures, Trans-Activators, Female, Neural plate, Signal Transduction, Transcription Factors, Developmental Biology, Morphogen |
| الوصف: | Anteroposterior (AP) patterning of the vertebrate neural plate is initiated during gastrulation and is regulated by Spemann’s organizer and its derivatives. The prevailing model for AP patterning predicts a caudally increasing gradient of a ‘transformer’ which posteriorizes anteriorly specified neural cells. However, the molecular identity of the transforming gradient has remained elusive. We show that in Xenopus embryos (1) dose-dependent Wnt signalling is both necessary and sufficient for AP patterning of the neuraxis, (2) Wnt/β-catenin signalling occurs in a direct and long-range fashion within the ectoderm, and (3) that there is an endogenous AP gradient of Wnt/β-catenin signalling in the presumptive neural plate of the Xenopus gastrula. Our results indicate that an activity gradient of Wnt/β-catenin signalling acts as transforming morphogen to pattern the Xenopus central nervous system. |
| تدمد: | 1477-9129 0950-1991 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2cfc7c2d9e25c8127181ef5900db33 https://doi.org/10.1242/dev.128.21.4189 |
| رقم الأكسشن: | edsair.doi.dedup.....0b2cfc7c2d9e25c8127181ef5900db33 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779129 09501991 |
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