Metabolism of Inorganic Arsenic in Mice Lacking Genes Encoding GST-P, GST-M, and GST-T
| العنوان: | Metabolism of Inorganic Arsenic in Mice Lacking Genes Encoding GST-P, GST-M, and GST-T |
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| المؤلفون: | Christelle Douillet, Beverly H. Koller, Miroslav Stýblo |
| المصدر: | Chem Res Toxicol |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | inorganic chemicals, Inorganic arsenic, Chemistry, Drinking Water, chemistry.chemical_element, Environmental Exposure, General Medicine, Metabolism, Urine, Toxicology, Molecular biology, Article, Arsenic, Glutathione transferase, Mice, Genotype, Animals, Gene, Glutathione Transferase |
| الوصف: | To investigate the role of glutathione transferases (GSTs) in the metabolism of inorganic arsenic (iAs), we compared the disposition of iAs and its metabolites in wild-type mice and mice lacking genes encoding GST-P, -M and -T after exposure to 100 ppb iAs in drinking water. We found no differences between the two genotypes in the concentrations of total arsenic or arsenic species in urine, liver, and kidneys. No genotype-dependent differences were found in proportions of arsenicals in the tissues, and only small differences were observed in the urine. Thus, under these conditions, GST-P, -M and -T did not play a significant role in iAs metabolism in mice. |
| تدمد: | 1520-5010 0893-228X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf224b00a33e46e39490bb3b7eebbb5 https://doi.org/10.1021/acs.chemrestox.0c00273 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0cf224b00a33e46e39490bb3b7eebbb5 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205010 0893228X |
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