Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations
العنوان: | Analysis of the genetic ancestry of patients with oral clefts from South American admixed populations |
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المؤلفون: | Fernando A. Poletta, Sidney Emanuel Batista dos Santos, Camilla Dutra Vieira-Machado, Alexandre R. Vieira, Luiz Carlos Santana da Silva, Juan C. Mereb, Iêda M. Orioli, Eduardo E. Castilla, Cláudia Maria da Rocha Martins, Flávia Martinez de Carvalho |
المصدر: | European Journal of Oral Sciences. 124:406-411 |
بيانات النشر: | Wiley, 2016. |
سنة النشر: | 2016 |
مصطلحات موضوعية: | 0301 basic medicine, Genetics, medicine.medical_specialty, Genotype, Cleft Lip, Genetic genealogy, Ethnic group, 030206 dentistry, 030105 genetics & heredity, Biology, White People, Cleft Palate, 03 medical and health sciences, 0302 clinical medicine, South american, Statistical significance, Epidemiology, medicine, Humans, In patient, Indel, General Dentistry, Genotyping, Brazil |
الوصف: | Increased susceptibility to cleft lip, with or without cleft palate (CL±P) has been observed in South America, as related to Amerindian ancestry, using epidemiological data, uniparental markers, and blood groups. In this study, it was evaluated whether this increased risk remains when Amerindian ancestry is estimated using autosomal markers and considered in the predictive model. Ancestry was estimated through genotyping 62 insertion and deletion (INDEL) markers in sample sets of patients with CL±P, patients with cleft palate (CP), and controls, from Patagonia in southern Argentina and Belém in northern Brazil. The Amerindian ancestry in patients from Patagonia with CL±P was greater than in controls although it did not reach statistical significance. The European ancestry in patients with CL±P from Belém and in patients with CP from Belém and Patagonia was higher than in controls and statistically significant for patients with CP who were from Belém. This high contribution of European genetic ancestry among patients with CP who were from Belém has not been previously observed in American populations. Our results do not corroborate the currently accepted risks for CL±P and CP estimated by epidemiological studies in the North American populations and probably reflect the higher admixture found in South American ethnic groups when compared with the same ethnic groups from the North American populations. |
تدمد: | 0909-8836 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db7db3b2819c0addf8f15b9d3c37ec6 https://doi.org/10.1111/eos.12275 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....0db7db3b2819c0addf8f15b9d3c37ec6 |
قاعدة البيانات: | OpenAIRE |
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