Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population
| العنوان: | Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population |
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| المؤلفون: | Wanjian Gu, Harvest F. Gu, Haixu Hu, Yuanrui Tian, Chong Shen, Mengxia Li, Juan Su, Hui Wang, Ting Zhang |
| المصدر: | BMJ Open Sport & Exercise Medicine, Vol 6, Iss 1 (2020) BMJ Open Sport — Exercise Medicine |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Gerontology, obesity, medicine.medical_specialty, Medicine (General), Population, Physical Therapy, Sports Therapy and Rehabilitation, Physical exercise, Single-nucleotide polymorphism, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, R5-920, university, Intervention (counseling), Heart rate, Medicine, genetics, Orthopedics and Sports Medicine, 030212 general & internal medicine, education, Original Research, education.field_of_study, exercise, business.industry, Public health, public health, medicine.disease, Obesity, Cohort, business |
| الوصف: | ObjectivePhysical inactivity inChinese youth students particularly in senior high schools, who participate inthe National Higher Education Entrance Examination (NCEE) is very common. Inorder to explore the beneficial effects from physical exercise and education afterNCEE, we performed a Physicalexercise Intervention Program in the Youth (PiPy) to evaluate the interaction with PPARγ genetic variants on cardiovascular and metabolicparameters.MethodsA total of 772 freshmen (males 610/females162) from high schools to university were recruited into the PiPy cohort, which was designedaccording to the National Student Health Standards in China. Anthropometric data were collected, whilephysical activities and body composition at the baseline of PiPy cohort weremeasured with SECAprotocols. Eighttagged single nucleotide polymorphisms (SNPs) in the PPARγ gene were genotyped with TaqMan allelicdiscrimination.ResultsAfter physical exercise intervention forthree months, in parallel with increased physical activities, BMI and skeletalmuscle content in all subjects was enhanced, while heart rate and bloodpressures were decreased. Furthermore, SNPs in 5’-UTR of the PPARγ gene, including rs2920502,rs9817428 and rs2972164, were found to be associated with the changes of BMI.Body weight in the subjects with BMI 2 were increased,while the obese subjects (BMI ≥24.0 kg/m2) decreased.ConclusionThe present study for the first timedemonstrated that the PiPy could improve cardio-metabolic parameters such asheart rate, blood pressures and BMI for Chinese youth students after NCEE, inwhich the genetic interactive effects of PPARγ should be included into obesityintervention. |
| اللغة: | English |
| تدمد: | 2055-7647 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebc94eac5d3eb902053afdcf0d9f0ea https://bmjopensem.bmj.com/content/6/1/e000681.full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0ebc94eac5d3eb902053afdcf0d9f0ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20557647 |
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