التفاصيل البيبلوغرافية
| العنوان: |
Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative |
| المؤلفون: |
Henrik Harms, Max Crüsemann, Tanja Schneider, Nicole Merten, Simon Stephan Martin Stölben, Gabriele M. König, Michael Gütschow, Peter Hufendiek, Idris Arslan, Stefan Kehraus |
| المصدر: |
Planta Medica. 83:1044-1052 |
| بيانات النشر: |
Georg Thieme Verlag KG, 2017. |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
0301 basic medicine, natural product, Pharmaceutical Science, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, acetosellin, polyketide, Drug Discovery, isotope labeling, 5',6'-dihydroxyacetosellin, fermentation, Carbon Isotopes, Molecular Structure, biology, Ascomycota, Drug discovery, structure analysis, unclassified drug, chemical labeling, Biochemistry, Molecular Medicine, biological product, carbon 13, Stereochemistry, Epicoccum nigrum, fungus culture, Fungus, chemistry, Didymellaceae, Article, 03 medical and health sciences, Polyketide, Biosynthesis, controlled study, Epicoccum nigrum 749, fungus isolation, 5',6'dihydroxyacetosellin, Pharmacology, The authors declare no conflict of interest. [Ascomycota/*chemistry/metabolism, Biological Products/*chemistry/metabolism, Carbon Isotopes/analysis, Polyketides/*chemistry/metabolismCOIS- Conflict of Interest], Biological Products, nonhuman, Natural product, 010405 organic chemistry, carbon, Organic Chemistry, biology.organism_classification, azaphilones, drug development, Ascomycetes, 0104 chemical sciences, 030104 developmental biology, Complementary and alternative medicine, Polyketides, chemical structure, extraction, biosynthesis, metabolism, Derivative (chemistry) |
| الوصف: |
Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds acetosellin and 5′,6′-dihydroxyacetosellin. The latter is a new natural product. The biosynthesis of these polyketide-type compounds is intriguing, since two polyketide chains are assembled to the final product. Here we performed 13 C labeling studies on solid cultures to prove this hypothesis for acetosellin biosynthesis. © 2017 Georg Thieme Verlag KG Stuttgart. New York. |
| تدمد: |
1439-0221
0032-0943 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51e83dff76d995cc8ffe626bdabb21
https://doi.org/10.1055/s-0042-124493 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....0f51e83dff76d995cc8ffe626bdabb21 |
| قاعدة البيانات: |
OpenAIRE |
