Presurgical platelet–lymphocyte ratio for prognosis in advanced hypopharyngeal squamous cell carcinoma in individuals undergoing radical resection
| العنوان: | Presurgical platelet–lymphocyte ratio for prognosis in advanced hypopharyngeal squamous cell carcinoma in individuals undergoing radical resection |
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| المؤلفون: | Chuanyao Lin, Xiaohui Shen, Hong Chen, Dengbin Ma, Xiaoyun Qian, Ao Li, Shenghua Song, Xia Gao |
| المصدر: | Acta Oto-Laryngologica. 141:537-543 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Lymphocyte, Laryngectomy, Gastroenterology, Hypopharyngeal Carcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Recurrence free survival, Preoperative Care, medicine, Overall survival, Humans, Lymphocyte Count, Neutrophil to lymphocyte ratio, 030223 otorhinolaryngology, Aged, Retrospective Studies, Platelet lymphocyte ratio, Aged, 80 and over, Hypopharyngeal Neoplasms, Platelet Count, Squamous Cell Carcinoma of Head and Neck, business.industry, Margins of Excision, General Medicine, Middle Aged, Prognosis, Survival Analysis, body regions, medicine.anatomical_structure, ROC Curve, Otorhinolaryngology, 030220 oncology & carcinogenesis, Hypopharyngeal squamous cell carcinoma, Neck Dissection, Female, Neoplasm Recurrence, Local, Radical resection, business, Follow-Up Studies |
| الوصف: | Patient prognosis in hypopharyngeal carcinoma remains difficult to predict, necessitating new, readily available biomarkers.Platelet-lymphocyte ratio (PLR)'s effects on recurrence-free survival (RFS) and overall survival (OS) were evaluated in individuals undergoing radical resection for advanced hypopharyngeal squamous cell carcinoma (HSCC).A total of 89 patients were retrospectively assessed. PLR, and derived neutrophil-lymphocyte (dNLR) and neutrophil-lymphocyte (NLR) ratios were determined based on complete blood count. Then, the prognostic values of PLR, dNLR and NLR were assessed by univariate and multivariate Cox regression analyses adjusted for disease-specific prognostic factors. Endpoints of interest were RFS and OS.The optimal cutoff of PLR was 98.815, based on which individuals were categorized into the high- (PLR ≥98.815) and low- (PLR98.815) PLR groups. High PLR (Elevated PLR has associations with increased risk of recurrence and reduced survival in advanced HSCC cases undergoing radical resection. High presurgical PLR may independently predict RFS. Therefore, further multi-institutional prospective studies are needed to better characterize the role of pre-operative blood PLR as prognostic factors in HSCC. |
| تدمد: | 1651-2251 0001-6489 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6ebd482544f74c94d986b0558a8cc8 https://doi.org/10.1080/00016489.2021.1891456 |
| رقم الأكسشن: | edsair.doi.dedup.....0f6ebd482544f74c94d986b0558a8cc8 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 16512251 00016489 |
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