Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019–2020
| العنوان: | Influenza Vaccine Effectiveness Against Hospitalization in the United States, 2019–2020 |
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| المؤلفون: | Fernanda P. Silveira, Amelia Drennan, Rebecca Kondor, Manjusha Gaglani, Shoshona Le, Richard K. Zimmerman, Briana Krantz, Kailey Hughes, Adam S. Lauring, Bethany Alicie, Yuwei Zhu, Arnold S. Monto, Arundhati Rao, Manish M. Patel, K G Balasubramani, Joshua G. Petrie, Heath White, Christopher Trabue, Manohar Mutnal, Donald B Middleton, Nicole Wheeler, Mark W Tenforde, Karen Speer, Lisa M Keong, Thomas J. Stark, Sean G Saul, Lori Stiefel, Kevin Chang, Jill M. Ferdinands, Ryan E. Malosh, Mohamed Yassin, Shekhar Ghamande, Emily T. Martin, Chandni Raiyani, Rendi McHenry, Natasha B. Halasa, Jan Orga, Kelsey Bounds, Tresa McNeal, John W Williams, Donna Carillo, Lydia Clipper, Lois Lamerato, Heather Eng, Alejandro Arroliga, Mary Patricia Nowalk, H. Keipp Talbot, Claudia Guevara Pulido, Dayna Wyatt, Emily Sedillo, Alina Simion, Tnelda Zunie, Zhouwen Liu, Kempapura Murthy, Laura Adams, Stephanie Longmire, John Barnes, Juliana Almeida da Silva, Anurag Malani, Kellie Graves, Samantha M Olson, Lynn Peterson |
| المصدر: | J Infect Dis |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Influenza vaccine, Orthomyxoviridae, Vaccine Efficacy, Older population, Immunocompromised Host, Major Articles and Brief Reports, 03 medical and health sciences, Influenza A Virus, H1N1 Subtype, 0302 clinical medicine, Internal medicine, Influenza, Human, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, Aged, Aged, 80 and over, Respiratory illness, biology, business.industry, Influenza A Virus, H3N2 Subtype, Vaccination, Confounding, virus diseases, Middle Aged, biology.organism_classification, United States, Confidence interval, Hospitalization, 030104 developmental biology, Infectious Diseases, Influenza Vaccines, Case-Control Studies, Female, Seasons, business |
| الوصف: | Background Influenza causes significant morbidity and mortality and stresses hospital resources during periods of increased circulation. We evaluated the effectiveness of the 2019–2020 influenza vaccine against influenza-associated hospitalization in the United States. Methods We included adults hospitalized with acute respiratory illness at 14 hospitals and tested for influenza viruses by reserve-transcription polymerase chain reaction. Vaccine effectiveness (VE) was estimated by comparing the odds of current-season influenza vaccination in test-positive influenza cases vs test-negative controls, adjusting for confounders. VE was stratified by age and major circulating influenza types along with A(H1N1)pdm09 genetic subgroups. Results A total of 3116 participants were included, including 18% (n = 553) influenza-positive cases. Median age was 63 years. Sixty-seven percent (n = 2079) received vaccination. Overall adjusted VE against influenza viruses was 41% (95% confidence interval [CI], 27%–52%). VE against A(H1N1)pdm09 viruses was 40% (95% CI, 24%–53%) and 33% against B viruses (95% CI, 0–56%). Of the 2 major A(H1N1)pdm09 subgroups (representing 90% of sequenced H1N1 viruses), VE against one group (5A + 187A,189E) was 59% (95% CI, 34%–75%) whereas no VE was observed against the other group (5A + 156K) (–1% [95% CI, –61% to 37%]). Conclusions In a primarily older population, influenza vaccination was associated with a 41% reduction in risk of hospitalized influenza illness. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f9a506243267f743be1b5de1d722e1 https://doi.org/10.1093/infdis/jiaa800 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....11f9a506243267f743be1b5de1d722e1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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