Gold nano-particles (AuNPs) carrying miR-326 targets PDK1/AKT/c-myc axis in hepatocellular carcinoma
| العنوان: | Gold nano-particles (AuNPs) carrying miR-326 targets PDK1/AKT/c-myc axis in hepatocellular carcinoma |
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| المؤلفون: | Longguang He, Fan Xue, Siyao Che, Liangfu Li, Junwei Huang, Yichao Mo, Qinshou Chen, Dasheng Li, Zeru Lai, Sibo Pan, Zhiheng Wan |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology. 47:2830-2837 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Carcinoma, Hepatocellular, Epithelial-Mesenchymal Transition, Biomedical Engineering, Metal Nanoparticles, Pharmaceutical Science, Medicine (miscellaneous), 02 engineering and technology, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, In vivo, Cell Line, Tumor, microRNA, medicine, Humans, Molecular Targeted Therapy, Protein kinase B, Cell Proliferation, Drug Carriers, Chemistry, Cell growth, Liver Neoplasms, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Cancer, General Medicine, 021001 nanoscience & nanotechnology, medicine.disease, MicroRNAs, Cell culture, Apoptosis, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Cancer research, Gold, 0210 nano-technology, Proto-Oncogene Proteins c-akt, Biotechnology |
| الوصف: | Abnormal expression of microRNAs (miRNAs) contributes to tumour growth and invasion. MiR-326 expression often down-regulates in several kinds of cancer and low expression of miR-326 is linked with poor prognosis in cancer patients. In the present study, we aimed to explore the modulatory mechanism of miR-326 in hepatocellular carcinoma (HCC). miR-326 expression was significantly decreased in HCC cell lines and tissues. miR-326 decreased HCC cell growth by affecting cell-cycle progression and by promoting apoptosis. In addition, miR-326 inhibited HCC cell invasion by decreasing the EMT phenotype. We found that miR-326 functioned as a tumour suppressor by repressing its down-stream target PDK1. C-myc contributed to miR-326 down-regulation through binding at its promoter and inhibited its expression. Based on these results, we conducted a therapeutic experiment by using gold nano-particles (AuNPs) carrying miR-326. Restoration of miR-326 reduced tumour growth in vivo. Our findings suggest that miR-326 may be a candidate prognostic biomarker and a target for new therapies in HCC patients. |
| تدمد: | 2169-141X 2169-1401 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148c6ba131d7a9cf8f532e06c62ce3d4 https://doi.org/10.1080/21691401.2018.1489266 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....148c6ba131d7a9cf8f532e06c62ce3d4 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 2169141X 21691401 |
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