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Predictive value of plasma matrix metalloproteinase-9 concentrations for spontaneous haemorrhagic transformation in patients with acute ischaemic stroke: A cohort study in Chinese patients

التفاصيل البيبلوغرافية
العنوان: Predictive value of plasma matrix metalloproteinase-9 concentrations for spontaneous haemorrhagic transformation in patients with acute ischaemic stroke: A cohort study in Chinese patients
المؤلفون: Shihong Zhang, Bo Wu, Deren Wang, Ruozhen Yuan, Ming Liu, Simiao Wu, Xinhui Cao, Song Tan
المصدر: Journal of Clinical Neuroscience. 58:108-112
بيانات النشر: Elsevier BV, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Adult, Male, China, medicine.medical_specialty, 030204 cardiovascular system & hematology, Brain Ischemia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Asian People, Interquartile range, Physiology (medical), Internal medicine, Ischaemic stroke, Odds Ratio, medicine, Humans, In patient, Aged, Cerebral Hemorrhage, medicine.diagnostic_test, business.industry, Matrix metalloproteinase 9, Magnetic resonance imaging, General Medicine, Odds ratio, Middle Aged, Confidence interval, Stroke, Matrix Metalloproteinase 9, ROC Curve, Neurology, Cardiology, Female, Surgery, Neurology (clinical), business, Biomarkers, 030217 neurology & neurosurgery, Cohort study
الوصف: Whether matrix metalloproteinase 9 (MMP-9) concentrations in plasma predict risk of spontaneous haemorrhagic transformation (sHT) in acute ischaemic stroke is unclear. From 1 March 2003 to 27 February 2006, patients with acute ischaemic stroke admitted to West China Hospital within 24 h of onset and healthy controls were enrolled and blood samples obtained. Plasma MMP-9 concentrations were determined using enzyme-linked immunosorbent assay, and sHT was diagnosed based on brain computed tomography or magnetic resonance performed 3-14 d after stroke onset. MMP-9 concentrations were compared for sHT patients, non-sHT patients and healthy controls. The threshold concentration for predicting sHT was determined using receiver operating characteristic analysis and the association between MMP-9 concentration and sHT was tested. One hundred and sixty-eight stroke patients and 40 healthy controls were included. Spontaneous HT occurred in 17.3% (29/168) of stroke patients and median plasma MMP-9 concentration in the sHT subgroup [244.3 ng/mL; interquartile range (IQR), 190.6-431.4] was significantly higher than in the non-sHT subgroup (110.0 ng/mL; IQR, 54.4-172.2) as well as in healthy controls (63.3 ng/mL; IQR 37.9-84.9) (both P 0.001). We identified 181.7 ng/mL as the threshold MMP-9 concentration, for which the positive predictive value was 48% and the negative predictive value was 96%. After controlling for potential confounding factors, MMP-9 concentration181.7 ng/mL was an independent predictor of sHT (odds ratio 18.8, 95% confidence interval 6.0-58.5, P 0.001). Plasma MMP-9 concentration181.7 ng/mL within 24 h after stroke onset independently predicts sHT in patients with ischaemic stroke.
تدمد: 0967-5868
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1538795f8e030c52c3ef5c229daa5391
https://doi.org/10.1016/j.jocn.2018.09.014
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....1538795f8e030c52c3ef5c229daa5391
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09675868