A Novel SNP Associated with Nighttime Pulse Pressure in Young-Onset Hypertension Patients Could Be a Genetic Prognostic Factor for Cardiovascular Events in a General Cohort in Taiwan
| العنوان: | A Novel SNP Associated with Nighttime Pulse Pressure in Young-Onset Hypertension Patients Could Be a Genetic Prognostic Factor for Cardiovascular Events in a General Cohort in Taiwan |
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| المؤلفون: | Shing Jong Lin, Wen-Harn Pan, Chin Iuan Chen, Ting Yu Chiu, Hung Yun Ho, Jyh Hong Chen, Chih Tai Ting, Tsung-Hsien Lin, Sheng Hsiung Sheu, Wei-Chuan Tsai, Tse Min Lu, Jaw Wen Chen, Chia Min Chung, Hsin-Chou Yang, Wei Hsian Yin, Hsin Bang Leu |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 6, p e97919 (2014) |
| بيانات النشر: | Public Library of Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pathology, Epidemiology, lcsh:Medicine, Genome-wide association study, Blood Pressure, Kaplan-Meier Estimate, Vascular Medicine, Coronary artery disease, Cohort Studies, Medicine and Health Sciences, lcsh:Science, Multidisciplinary, Signal Processing, Computer-Assisted, Genomics, Blood Pressure Monitoring, Ambulatory, Prognosis, Pulse pressure, Circadian Rhythm, Chromosomes, Human, Pair 2, Cohort, Hypertension, Cardiology, Female, Anatomy, Cohort study, Research Article, Adult, medicine.medical_specialty, Ambulatory blood pressure, Taiwan, Polymorphism, Single Nucleotide, Internal medicine, medicine, Genome-Wide Association Studies, Genetics, Humans, Genetic Predisposition to Disease, Risk factor, Cardiovascular Disease Epidemiology, Genetic Association Studies, Clinical Genetics, Models, Genetic, business.industry, lcsh:R, Biology and Life Sciences, Computational Biology, Human Genetics, medicine.disease, Genome Analysis, Blood pressure, Genetic Loci, Cardiovascular Anatomy, lcsh:Q, business |
| الوصف: | BACKGROUND: Pulse pressure (PP) is a risk factor for cardiovascular disease. It has been reported that ambulatory blood pressure (BP) and nighttime BP parameters are heritable traits. However, the genetic association of pulse pressure and its clinical impact remain undetermined. METHOD AND RESULTS: We conducted a genome-wide association study of PP using ambulatory BP monitoring in young-onset hypertensive patients and found a significant association between nighttime PP and SNP rs897876 (p = 0.009) at chromosome 2p14, which contains the predicted gene FLJ16124. Young-onset hypertension patients carrying TT genotypes at rs897876 had higher nighttime PP than those with CT and CC genotypes (TT, 41.6 ± 7.3 mm Hg; CT, 39.1 ± 6.0 mm Hg; CC, 38.9 ± 6.3 mm Hg; p |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dc5f8d65e1377f267d802997103f13 http://europepmc.org/articles/PMC4043733 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....15dc5f8d65e1377f267d802997103f13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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