The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma
| العنوان: | The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma |
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| المؤلفون: | Sue Min Ooi, Ronald J. Cohen, Justin Vivian |
| المصدر: | International Urology and Nephrology. 41:559-565 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Nephrology, medicine.medical_specialty, Pathology, Urology, medicine.medical_treatment, Angiomyolipoma, Young Adult, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Proliferation Marker, neoplasms, Pathological, biology, business.industry, Kidney Neoplasms, Nephrectomy, Ki-67 Antigen, Ki-67, biology.protein, Epithelioid angiomyolipoma, Immunohistochemistry, Female, business, Biomarkers, Renal angiomyolipoma |
| الوصف: | Epithelioid angiomyolipoma (EAML) is a rare malignant variant of renal angiomyolipoma (AML). There were 34 cases of EAML reported in 25 studies (including this present study) over the past decade. About 68% were females and 32% males. The mean age was 40.1 years, 53% developed metastatic disease after nephrectomy, and eight patients had TSC. All cases are reported positive when stained with HMB-45 which also labels all classical AML. This study evaluates the use of Ki-67 (proliferation marker) in the pathological diagnosis of EAML and distinction from classical AML. Immunohistochemical reactions for Ki-67 were generated on multiple representative blocks of tissue obtained from two cases of HMB-45 positive EAML and four cases of classic AML and the percentage of positively staining cells estimated. Both cases of EAML were strongly positive for Ki-67 while all four classic AML were completely negative. The Ki67 is a useful marker in which distinguishes the malignant epithelioid variant of AML from classic AML. |
| تدمد: | 1573-2584 0301-1623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e6161d8ce388a291d985c6cb061c85 https://doi.org/10.1007/s11255-008-9473-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....15e6161d8ce388a291d985c6cb061c85 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15732584 03011623 |
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