Emerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges
| العنوان: | Emerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges |
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| المؤلفون: | Philippe Busson, Caroline Even, François-Régis Ferrand, Anna Makowska, Valentin Baloche, Udo Kontny |
| المساهمون: | Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Expert Opinion on Therapeutic Targets Expert Opinion on Therapeutic Targets, Taylor & Francis, 2020, 24 (6), pp.545-558. ⟨10.1080/14728222.2020.1751820⟩ |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Epstein-Barr Virus Infections, Herpesvirus 4, Human, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Context (language use), Biology, Genome, Virus, 03 medical and health sciences, 0302 clinical medicine, Immune system, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Epigenetics, ComputingMilieux_MISCELLANEOUS, Galectin, Pharmacology, Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms, Oncogenes, medicine.disease, 3. Good health, Immune Modulators, 030104 developmental biology, Nasopharyngeal carcinoma, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine |
| الوصف: | Introduction: Nasopharyngeal carcinoma (NPC) is a major public health problem in several countries, especially those in Southeast Asia and North Africa. In its typical poorly differentiated form, the Epstein-Barr virus (EBV) genome is present in the nuclei of all malignant cells with restricted expression of a few viral genes. The malignant phenotype of NPC cells results from the influence of these viral products in combination with cellular genetic, epigenetic and functional alterations. With regard to host/tumor interactions, NPC is a remarkable example of immune escape in the context of a hot tumor.Areas covered: This article has an emphasis on emerging therapeutic targets that are considered upstream or at an early stage of clinical application. It examines targets related to cellular oncogenic alterations, latent EBV infection and tumor interactions with the immune system.Expert opinion: There is a remarkable emergence of new agents that target EBV products. The clinical application of these agents would benefit from a systematic and comprehensive molecular classification of NPCs and from easy access to pre-clinical models in public repositories. There is a strong rationale for more investigations on the potential of immune modulators, especially those related to NK cells. |
| تدمد: | 1744-7631 1472-8222 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f51b96ac3851f4445a0c514c8f89d8 https://doi.org/10.1080/14728222.2020.1751820 |
| رقم الأكسشن: | edsair.doi.dedup.....16f51b96ac3851f4445a0c514c8f89d8 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17447631 14728222 |
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