Viper Venom Disintegrins and Related Molecules
| العنوان: | Viper Venom Disintegrins and Related Molecules |
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| المؤلفون: | Stefan Niewiarowski, Mary Ann McLane, Cezary Marcinkiewicz, Senadhi Vijay-Kumar, Iwona Wierzbicka-Patynowski |
| المصدر: | Experimental Biology and Medicine. 219:109-119 |
| بيانات النشر: | SAGE Publications, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | VIPeR, Integrin receptors, Disintegrins, Molecular Sequence Data, Nanotechnology, Viper Venoms, Biology, General Biochemistry, Genetics and Molecular Biology, Structure and function, carbohydrates (lipids), Sequence homology, Biochemistry, Endopeptidases, Disintegrin, biology.protein, Animals, Humans, Amino Acid Sequence, Receptor, Dimerization, Sequence Alignment, Platelet Aggregation Inhibitors |
| الوصف: | The term “disintegrin” was first used in 1990 to describe a group of viper venom-derived, nonenzymatic small proteins that shared numerous structural and functional properties. These proteins, which have been found in a great number of viper species studied since that time possess both a remarkable sequence homology and an equally notable variability in potency and selectivity in their interactions with integrin receptors. The discovery that small disintegrins may actually have been derived from much larger mosaic proteins possessing catalytic activity, and that species other than snakes (both plant and animal) produce proteins containing disintegrin-like domains, has led to much research related to both the proteins themselves and the receptors to which they bind. The purpose of this review is to discuss the literature and the authors'own data on the structure and function of disintegrins and their relevance to the studies on proteins containing disintegrin-like domains, such as hemorrhagins and ... |
| تدمد: | 1535-3699 1535-3702 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f650c015578e3791ab67a5ec7a3c85 https://doi.org/10.3181/00379727-219-44322 |
| رقم الأكسشن: | edsair.doi.dedup.....16f650c015578e3791ab67a5ec7a3c85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15353699 15353702 |
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