Concomitant LATE‐NC in Alzheimer's disease is not associated with increased tau or amyloid‐β pathological burden
| العنوان: | Concomitant LATE‐NC in Alzheimer's disease is not associated with increased tau or amyloid‐β pathological burden |
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| المؤلفون: | Alan J. Thomas, Daniel Erskine, David J. Koss, Johannes Attems, Lauren Walker, Kirsty E. McAleese, Mary Johnson |
| المصدر: | Neuropathology and Applied Neurobiology. 46:722-734 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Histology, Tau pathology, Amyloid β, Encephalopathy, Hyperphosphorylation, tau Proteins, Disease, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Physiology (medical), Internal medicine, Humans, Medicine, Cognitive Dysfunction, Cognitive decline, Pathological, Neuropathology, Aged, Aged, 80 and over, Amyloid beta-Peptides, business.industry, medicine.disease, DNA-Binding Proteins, 030104 developmental biology, Neurology, Concomitant, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Aims Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is present in approximately 50% of Alzheimer's disease (AD) cases and is associated with accelerated cognitive decline. Studies indicate a potential synergistic relationship between LATE-NC and hyperphosphorylated tau. It is unknown if LATE-NC is an independent driver of cognitive impairment or exerts its influence through synergistic relationships with tau. This cliniconeuropathological study investigated the impact of LATE-NC on quantified measures of AD-associated pathology and its impact on clinical measures. Methods A total of 61 AD cases underwent neuropathological assessment for LATE-NC and quantitative assessment [area covered by immunoreactivity (IR)] for early conformational tau (MC-1), late-stage hyperphosphorylated tau (AT8) and amyloid-β in the amygdala and five neocortical regions. Clinical measures included age of disease onset, final Mini-Mental State Examination (MMSE) score and rate of cognitive decline. Results LATE-NC was present in 41 AD cases (AD/LATE-NC; 67.2%). No significant differences in MC-1-IR, AT8-IR or 4G8-IR were observed in any region between AD/LATE-NC and AD without LATE-NC, indicating no accelerated aggregation or hyperphosphorylation of tau proteins in the AD/LATE-NC cases. Final MMSE was significantly lower in AD/LATE-NC cases and was significantly associated with LATE-NC score even when controlled for the presence of both MC-1-IR and AT8-IR (P = 0.009). Conclusion The presence of LATE-NC in AD is not associated with an increase in the burden of early or late tau or Aβ pathology. LATE-NC is associated with a lower final MMSE score independent of tau pathology. |
| تدمد: | 1365-2990 0305-1846 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179e0c3f1e63dff050df80060920b00d https://doi.org/10.1111/nan.12664 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....179e0c3f1e63dff050df80060920b00d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652990 03051846 |
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