Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points
| العنوان: | Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points |
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| المؤلفون: | Murat Cetinkaya, Semra Kahraman, Hakan Yelke, Z. Atayurt, Yesim Kumtepe Colakoglu, Caroline Pirkevi |
| المصدر: | Journal of Assisted Reproduction and Genetics |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Morphokinetics, medicine.medical_specialty, Pregnancy Rate, Embryonic Development, Biology, Cleavage (embryo), Pregnancy, Internal medicine, Synchronicity, Obstetrics and Gynaecology, Genetics, medicine, Humans, Genetics(clinical), Embryo Implantation, Blastocyst, Genetics (clinical), Cleavage, Time-lapse imaging, Obstetrics and Gynecology, General Medicine, Embryo Transfer, Embryo transfer, Embryo Biology, medicine.anatomical_structure, Endocrinology, Reproductive Medicine, Infertility, embryonic structures, Female, Selection criterion, Biological system, Developmental Biology |
| الوصف: | Purpose Morphology alone is not enough for the selection of the embryo (s) with the highest implantation potential and time-lapse imaging has added embryo development kinetics as another selection criterion. Therefore, a combination of morphology with kinetics has inspired a new field termed “morphokinetics”, providing a new way of evaluating and selecting embryos. The aim of the study was to identify a criterion solely based on morphokinetic data and available up to the 8-cell stage (t8) to predict blastocyst formation and quality. Methods The study included 3,354 embryos, with annotations up to t8, and cultured until day 5 from 626 infertile patients. A total of 17 kinetic expressions, either absolute cleavage timings and time intervals or time ratios were tested retrospectively for the prediction of blastocyst formation and quality. Results Relative timings (t8-t5, the cleavage synchronicity from 4 to 8 cells and from 2 to 8 cells) were found to be better indicators of blastocyst formation and quality when compared to absolute time-points. Especially, the cleavage synchronicity from 2 to 8 cells (CS2-8) = ((t3-t2) + (t5-t4))/(t8-t2)) was found to be the best predictor available on day 3 for blastocyst formation and quality (AUC:0.786; sensitivity: 83.43; specificity: 62.46). Conclusions Time intervals and relative ratios based on selected cleavage cycles defining synchronicity allowed a specific analysis providing high predictivity of blastocyst formation and quality. Electronic supplementary material The online version of this article (doi:10.1007/s10815-014-0341-x) contains supplementary material, which is available to authorized users. |
| تدمد: | 1573-7330 1058-0468 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18eeaac1a4740de487ca3b1c51a4af2e https://doi.org/10.1007/s10815-014-0341-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....18eeaac1a4740de487ca3b1c51a4af2e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737330 10580468 |
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