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Evidence for a novel subcortical mechanism for posterior cingulate cortex atrophy in HIV peripheral neuropathy

التفاصيل البيبلوغرافية
العنوان: Evidence for a novel subcortical mechanism for posterior cingulate cortex atrophy in HIV peripheral neuropathy
المؤلفون: Gregory G. Brown, Stephanie Corkran, Earl Umbao, Alan Tong, Eelke Visser, Zachary Calvo, Mark Jenkinson, J. Hampton Atkinson, Alan N. Simmons, Igor Grant, Florin Vaida, Mary Beth Bilder, Sarah L. Archibald, John R Keltner, Ronald J. Ellis, Aleks Sheringov, Colm G. Connolly, Rohit Mande, Donald Franklin, Gagandeep Sahota, Alyssa Dasca
المصدر: J Neurovirol
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Neurology, Thalamus, HIV Infections, Gyrus Cinguli, Article, White matter, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Atrophy, Virology, Internal medicine, medicine, Humans, Paresthesia, Aged, Brain Mapping, business.industry, HIV, Peripheral Nervous System Diseases, Middle Aged, medicine.disease, Magnetic Resonance Imaging, White Matter, Cross-Sectional Studies, 030104 developmental biology, medicine.anatomical_structure, Peripheral neuropathy, Posterior cingulate, Neuropathic pain, Brain size, Cardiology, Neuralgia, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
الوصف: We previously reported that neuropathic pain was associated with smaller posterior cingulate cortical (PCC) volumes, suggesting that a smaller/dysfunctional PCC may contribute to development of pain via impaired mind wandering. A gap in our previous report was lack of evidence for a mechanism for the genesis of PCC atrophy in HIV peripheral neuropathy. Here we investigate if volumetric differences in the subcortex for those with neuropathic paresthesia may contribute to smaller PCC volumes, potentially through deafferentation of ascending white matter tracts resulting from peripheral nerve damage in HIV neuropathy. Since neuropathic pain and paresthesia are highly correlated, statistical decomposition was used to separate pain and paresthesia symptoms to determine which regions of brain atrophy are associated with both pain and paresthesia and which are associated separately with pain or paresthesia. HIV+ individuals (N = 233) with and without paresthesia in a multisite study underwent structural brain magnetic resonance imaging. Voxel-based morphometry and a segmentation/registration tool were used to investigate regional brain volume changes associated with paresthesia. Analysis of decomposed variables found that smaller midbrain and thalamus volumes were associated with paresthesia rather than pain. However, atrophy in the PCC was related to both pain and paresthesia. Peak thalamic atrophy (p = 0.004; MNI x = − 14, y = − 24, z = − 2) for more severe paresthesia was in a region with reciprocal connections with the PCC. This provides initial evidence that smaller PCC volumes in HIV peripheral neuropathy are related to ascending white matter deafferentation caused by small fiber damage observed in HIV peripheral neuropathy.
تدمد: 1538-2443
1355-0284
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198343f14fe928c1335eee9020fcbdbc
https://doi.org/10.1007/s13365-020-00850-3
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....198343f14fe928c1335eee9020fcbdbc
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15382443
13550284