Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015
| العنوان: | Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015 |
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| المؤلفون: | Paola Stefanelli, Silje Vermedal Hoegh, Qiushui He, Lena Wehlin, Marjolein van Gent, Jussi Mertsola, Sophie Guillot, Kari Auranen, Margrethe Greve-Isdahl, Norman K. Fry, Didrik F. Vestrheim, Margaretha Ljungman, Alex-Mikael Barkoff, Denis Pierard, Guy A. M. Berbers, Kevin Markey, Tine Dalby |
| المساهمون: | Supporting clinical sciences, Microbiology and Infection Control, Clinical Biology |
| المصدر: | Barkoff, A-M, Mertsola, J, Pierard, D, Dalby, T, Vermedal Hoegh, S, Guillot, S, Stefanelli, P, van Gent, M, Berbers, G, Vestrheim, D F, Greve-Isdahl, M, Wehlin, L, Ljungman, M, Fry, N K, Markey, K, Auranen, K & He, Q 2018, ' Surveillance of circulating bordetella pertussis strains in Europe during 1998 to 2015 ', Journal of Clinical Microbiology, vol. 56, no. 5, e01998-17, pp. e01998-17 . https://doi.org/10.1128/JCM.01998-17 |
| بيانات النشر: | American Society for Microbiology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | DNA, Bacterial, 0301 basic medicine, Microbiology (medical), Serotype, Genotyping, Bordetella pertussis, Genotype, Whooping Cough, 030106 microbiology, Population, Bordetella pertussis/genetics, Multiple Loci VNTR Analysis, Serogroup, Whooping Cough/epidemiology, Europe/epidemiology, Microbiology, Pertussis Vaccine/immunology, 03 medical and health sciences, Journal Article, medicine, Pulsed-field gel electrophoresis, Humans, Serotyping, education, Whooping cough, Pertussis Vaccine, education.field_of_study, biology, MLVA, Genetic Variation, Bacteriology, Genome, Bacterial/genetics, Sequence Analysis, DNA, PFGE, medicine.disease, biology.organism_classification, Molecular Typing, Europe, DNA, Bacterial/genetics, Genes, Bacterial, Epidemiological Monitoring, Genes, Bacterial/genetics, Pertussis vaccine, Genome, Bacterial, medicine.drug |
| الوصف: | One reason for increased pertussis incidence is the adaptation of Bordetella pertussis to vaccine-induced immunity by modulating its genomic structure. This study, EUpert IV, includes 265 isolates collected from nine European countries during 2012 to 2015 ( n = 265) and compares the results to previous EUpert I to III studies (1998 to 2009). The analyses included genotyping, serotyping, pulsed-field gel electrophoresis (PFGE), and multilocus variable-number tandem-repeat analysis (MLVA). Genotyping results showed only small variations among the common virulence genes of B. pertussis . The frequencies of serotypes Fim2 and Fim3 varied among the four collections. Genomic analyses showed that MLVA type 27 increased to 80% between the periods of 1998 to 2001 and 2012 to 2015. Two PFGE profiles, BpSR3 (29.4%) and BpSR10 (27.2%), constituted more than 50% of the circulating isolates in the present collection. Our study indicates that the European B. pertussis population is changing and became more homogenous after the introduction of acellular pertussis vaccines. |
| وصف الملف: | application/pdf |
| تدمد: | 1098-660X 0095-1137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198357e4dcb2044123e390a04aec1fef https://doi.org/10.1128/jcm.01998-17 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....198357e4dcb2044123e390a04aec1fef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1098660X 00951137 |
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