Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption
| العنوان: | Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption |
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| المؤلفون: | Luigi Viganò, Silvio De Flora, Marco Gobbi, Giuseppe Mascolo, Claudio Roscioli, Alberto Izzotti, Giovanna Guiso, Alberta Mandich |
| المصدر: | Aquatic toxicology 169 (2015): 223–239. doi:10.1016/j.aquatox.2015.10.022 info:cnr-pdr/source/autori:Vigano L.; De Flora S.; Gobbi M.; Guiso G.; Izzotti A.; Mandich A.; Mascolo G.; Roscioli C./titolo:Exposing native cyprinid (Barbus plebejus) juveniles to river sediments leads to gonadal alterations, genotoxic effects and thyroid disruption/doi:10.1016%2Fj.aquatox.2015.10.022/rivista:Aquatic toxicology/anno:2015/pagina_da:223/pagina_a:239/intervallo_pagine:223–239/volume:169 |
| بيانات النشر: | Elsevier BV, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Barbus juvenile, Intersex, DNA adducts, Thyroid hormones, Bile, River sediment, Geologic Sediments, Health, Toxicology and Mutagenesis, Cyprinidae, Thyroid Gland, Drainage basin, Zoology, Endocrine System, Aquatic Science, Vitellogenin, Rivers, Barbus plebejus, Tributary, Animals, Gonads, geography, Barbel, geography.geographical_feature_category, biology, Ecology, Aquatic animal, Environmental Exposure, Environmental exposure, biology.organism_classification, Gene Expression Regulation, Italy, Liver, biology.protein, Water Pollutants, Chemical |
| الوصف: | Juveniles (50 days post hatch) of a native cyprinid fish (Barbus plebejus) were exposed for 7 months to sediments from the River Lambro, a polluted tributary impairing the quality of the River Po for tens of kilometers from their confluence. Sediments were collected upstream of the city of Milan and downstream at the closure of the drainage basin of the River Lambro. Chemical analyses revealed the presence of a complex mixture of bioavailable endocrine-active chemicals, with higher exposure levels in the downstream section of the tributary. Mainly characterized by brominated flame retardants, alkylphenols, polychlorinated biphenyls, and minor co-occurring personal care products and natural hormones, the sediment contamination induced reproductive disorders, as well as other forms of endocrine disruption and toxicity. In particular, exposed male barbel exhibited higher biliary PAH-like metabolites, overexpression of the cyp1a gene, vitellogenin production in all specimens, the presence of oocytes (up to 22% intersex), degenerative alterations in their testis, liver fat vacuolization, a marked depression of total thyroxine (T4) and triiodothyronine (T3) plasma levels, and genotoxic damages determined as hepatic DNA adducts. These results clearly demonstrate that Lambro sediments alone are responsible for recognizable changes in the structure and function of the reproductive and, in general, the endocrine system of a native fish species. In the real environment, exposure to waterborne and food-web sources of chemicals are responsible for additional toxic loads, and the present findings thus provide evidence for a causal role of this tributary in the severe decline observed in barbel in recent decades and raise concern that the fish community of the River Po is exposed to endocrine-mediated health effects along tens of kilometres of its course. |
| تدمد: | 0166-445X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a90b3d4fb14a37487e2755d7e52177 https://doi.org/10.1016/j.aquatox.2015.10.022 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....19a90b3d4fb14a37487e2755d7e52177 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0166445X |
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