Performance of Narrow Band Imaging (NBI) and Photodynamic Diagnosis (PDD) Fluorescence Imaging Compared to White Light Cystoscopy (WLC) in Detecting Non-Muscle Invasive Bladder Cancer: A Systematic Review and Lesion-Level Diagnostic Meta-Analysis
| العنوان: | Performance of Narrow Band Imaging (NBI) and Photodynamic Diagnosis (PDD) Fluorescence Imaging Compared to White Light Cystoscopy (WLC) in Detecting Non-Muscle Invasive Bladder Cancer: A Systematic Review and Lesion-Level Diagnostic Meta-Analysis |
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| المؤلفون: | Giuseppe Broggi, Giovanni Cacciamani, Yair Lotan, J. Alfred Witjes, Indebir S. Gill, Siamak Daneshmand, Rosario Caltabiano, Andrea Cocci, Mihir M. Desai, Ashish M. Kamat, Angela B. Smith, Tamir Sholklapper, Giuseppe Morgia, Giorgio Ivan Russo |
| المصدر: | Cancers Cancers, Vol 13, Iss 4378, p 4378 (2021) Cancers, 13, 17 Cancers, 13 |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Fluorescence-lifetime imaging microscopy, PDD, narrow band imaging, blue light cystoscopy, Malignancy, law.invention, Lesion, accuracy meta-analysis, hexaminolevulinate, Randomized controlled trial, law, Biopsy, Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15], medicine, cystoscopy, 5-ALA, RC254-282, Bladder cancer, medicine.diagnostic_test, business.industry, photodynamic diagnosis fluorescence, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cystoscopy, medicine.disease, 5-aminolaevulinic acid, HAL, Oncology, Meta-analysis, bladder cancer, Radiology, Systematic Review, medicine.symptom, business |
| الوصف: | Simple Summary Bladder cancer is one of the most common malignancies in the United States with a majority of patients diagnosed with non-muscle invasive bladder cancer (NMIBC). Despite early detection and regular surveillance of most cases, recurrence and progression rates remain high. The aim of our systematic review and meta-analysis was to compare the sensitivity, specificity, and oncologic outcomes of photodynamic diagnosis (PDD) fluorescence, narrow band imaging (NBI), and conventional white light cystoscopy (WLC) in detecting NMIBC. Through the collection of prospective and randomized controlled trials, we demonstrated that tumor resection with either PDD and NBI exhibited greater diagnostic sensitivity compared to WLC alone. Our findings underscore the value of integrating these enhanced technologies as a part of the standard care for patients with suspected or confirmed NMIBC. Abstract Despite early detection and regular surveillance of non-muscle invasive bladder cancer (NMIBC), recurrence and progression rates remain exceedingly high for this highly prevalent malignancy. Limited visualization of malignant lesions with standard cystoscopy and associated false-negative biopsy rates have been the driving force for investigating alternative and adjunctive technologies for improved cystoscopy. The aim of our systematic review and meta-analysis was to compare the sensitivity, specificity, and oncologic outcomes of photodynamic diagnosis (PDD) fluorescence, narrow band imaging (NBI), and conventional white light cystoscopy (WLC) in detecting NMIBC. Out of 1,087 studies reviewed, 17 prospective non-randomized and randomized controlled trials met inclusion criteria for the study. We demonstrated that tumor resection with either PDD and NBI exhibited lower recurrence rates and greater diagnostic sensitivity compared to WLC alone. NBI demonstrated superior disease sensitivity and specificity as compared to WLC and an overall greater hierarchical summary receiver operative characteristic. Our findings are consistent with emerging guidelines and underscore the value of integrating these enhanced technologies as a part of the standard care for patients with suspected or confirmed NMIBC. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0cc627e67234cb5cddcab68b1ab24b http://europepmc.org/articles/PMC8431313 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1b0cc627e67234cb5cddcab68b1ab24b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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