Predictive and prognostic values of pretreatment functional imaging-based biomarkers in advanced-stage laryngeal cancer
| العنوان: | Predictive and prognostic values of pretreatment functional imaging-based biomarkers in advanced-stage laryngeal cancer |
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| المؤلفون: | Serdar Tarhan, Beyhan Cengiz Özyurt, Feray Aras, Gulgun Yilmaz Ovali, Görkem Eskiizmir |
| المصدر: | Volume: 8, Issue: 1 1-12 ENT Updates |
| بيانات النشر: | AVES Publishing Co., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Chemotherapy, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Cancer, Standardized uptake value, medicine.disease, Log-rank test, Functional imaging, Predictive,prognostic,imaging-based biomarkers,laryngeal cancer, Health Care Sciences and Services, Positron emission tomography, Adjuvant therapy, medicine, Effective diffusion coefficient, Radiology, Sağlık Bilimleri ve Hizmetleri, business |
| الوصف: | Objective: To determine the quantitative values of apparent diffusion coefficient (ADC), standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), metabolic tumor volume indexes (MTImax, and MTImean) using diffusion weighted-MRI (DW-MRI) and positron emission tomography/computed tomography (PET/CT), and analyze the predictive and prognostic values of these biomarkers in a homogenous group of patients with advanced-stage laryngeal cancer. Methods: Patients with newly diagnosed advanced-stage laryngeal cancer who had both DW-MRI and 18F-FDG PET/CT before treatment, and who had curative cancer treatment (surgery ± adjuvant therapy or radio ± chemotherapy) between 2011 and 2015 were included in this study. All patients were followed up clinically and radiologically, if necessary every 3 months for the first 2 years, every 4-6 months for year 3, and then annually thereafter. Results: Thirty-eight patients were retrospectively analyzed. Our analysis demonstrated statistically significant differences when the pretreatment SUV and MTImean value were compared between patients with stages III and IV. Standardized uptake value was also a predictive factor for N-stage. Moreover, a statistically significant difference was determined when patients with and without perinodal involvement (PNI) were compared. Log rank analysis demonstrated that none of functional imaging-based biomarkers had a prognostic role for oncological outcomes. Conclusion: Our results demonstrated that pretreatment SUV and MTImean values were predictive factors for staging, N-stage and PNI. Indeed, functional imaging-based biomarkers are promising, novel, non-invasive techniques that may provide additional information about tumor characteristics, treatment selection and prognosis in the near future. |
| وصف الملف: | application/pdf |
| تدمد: | 2149-6498 2149-7109 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c63babbd8cd2f79f37031aaad79c83e https://doi.org/10.2399/jmu.2018001008 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1c63babbd8cd2f79f37031aaad79c83e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21496498 21497109 |
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