Hutchinson-Gilford progeria syndrome: Rejuvenating old drugs to fight accelerated ageing
| العنوان: | Hutchinson-Gilford progeria syndrome: Rejuvenating old drugs to fight accelerated ageing |
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| المؤلفون: | Déborah Cardoso, Solenn M. Guilbert, Xavier Nissan, Antoine Muchir, Nicolas Lévy |
| المساهمون: | Institut des cellules souches pour le traitement et l'étude des maladies monogéniques (I-STEM), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Généthon, Association française contre les myopathies (AFM-Téléthon), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut de Myologie, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-18-CE14-0036,PAR-AGING,Le role de la PARylation sur l'apparition des troubles cardiovasculaires dans la progeria(2018), Centre de Recherche en Myologie, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Gestionnaire, Hal Sorbonne Université, Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Sorbonne Université (SU) |
| المصدر: | Methods Methods, 2020, ⟨10.1016/j.ymeth.2020.04.005⟩ Methods, Elsevier, 2020, ⟨10.1016/j.ymeth.2020.04.005⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Aging, media_common.quotation_subject, Drug repurposing, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Progeria, Pluripotent stem cells, medicine, Humans, Intensive care medicine, Molecular Biology, 030304 developmental biology, media_common, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 0303 health sciences, integumentary system, business.industry, 030302 biochemistry & molecular biology, Genetic disorder, High-throughput screening, nutritional and metabolic diseases, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Lamin Type A, medicine.disease, 3. Good health, Drug repositioning, Pharmaceutical Preparations, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, business, Hutchinson Gilford Progeria Syndrome |
| الوصف: | International audience; What if the next generation of successful treatments was hidden in the current pharmacopoeia? Identifying new indications for existing drugs, also called the drug repurposing or drug rediscovery process, is a highly efficient and low-cost strategy. First reported almost a century ago, drug repurposing has emerged as a valuable therapeutic option for diseases that do not have specific treatments and rare diseases, in particular. This review focuses on Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder that induces accelerated and precocious aging, for which drug repurposing has led to the discovery of several potential treatments over the past decade. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1046-2023 1095-9130 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2594f6fe98c5ab5d8b01e77c1001f8 https://hal.sorbonne-universite.fr/hal-02548462/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....1e2594f6fe98c5ab5d8b01e77c1001f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10462023 10959130 |
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