Incidence and risk factors of contrast-induced nephropathy after transcatheter arterial chemoembolization in hepatocellular carcinoma
| العنوان: | Incidence and risk factors of contrast-induced nephropathy after transcatheter arterial chemoembolization in hepatocellular carcinoma |
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| المؤلفون: | Satoru Kishi, Takamasa Ohki, Hiroko Ambe, Mari Aoe, Toyohiro Hashiba, Emi Furukawa, Ken Ohara, Yu Kurata, Takafumi Kanemitsu, Masahiro Ichikawa, Tomoko Honda, Katsunori Saito, Yoshiyasu Ogura, Naobumi Mise, Satoshi Furuse, Yuto Takenaka, Nobuo Toda |
| المصدر: | Clinical and Experimental Nephrology. 23:1141-1146 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Time Factors, Physiology, medicine.medical_treatment, 030232 urology & nephrology, Contrast-induced nephropathy, Contrast Media, Serum Albumin, Human, 030204 cardiovascular system & hematology, Risk Assessment, Gastroenterology, Nephropathy, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Physiology (medical), Internal medicine, medicine, Humans, Chemoembolization, Therapeutic, Tokyo, Transcatheter arterial chemoembolization, Aged, Retrospective Studies, Aged, 80 and over, Univariate analysis, business.industry, Incidence, Incidence (epidemiology), Liver Neoplasms, Odds ratio, Middle Aged, medicine.disease, Tumor Burden, Treatment Outcome, Nephrology, Hepatocellular carcinoma, Female, Kidney Diseases, Hemodialysis, business |
| الوصف: | Transcatheter arterial chemoembolization (TACE) is widely used for unresectable hepatocellular carcinoma (HCC). The purpose of this study was to investigate incidence and risk factors of contrast-induced nephropathy (CIN) after TACE in patients with HCC.In this single-center retrospective study, we examined 461 consecutive TACE sessions in 260 patients between January 2003 and October 2015. CIN was defined as an increase in serum creatinine levels by ≥ 0.5 mg/dl or ≥ 25% from baseline within 72 h after TACE. We calculated incidence rate of CIN and tried to identify its risk factors by logistic regression analysis.Twenty-one cases of CIN (5%) were observed in 461 TACE sessions. One patient required subsequent hemodialysis transiently. In univariate analysis, tumor size 5 cm [odds ratio (OR) 5.76, 95% confidence interval (CI) 2.34-14.14, p 0.001], chronic kidney disease (OR 2.54, 95% CI 1.05-6.14, p = 0.04), serum hemoglobin level [OR 0.79 (per 1 g/dl increase), 95% CI 0.64-0.98, p = 0.03] and serum albumin level [OR 0.44 (per 1 g/dl increase), 95% CI 0.19-1.02, p = 0.05] were associated with the development of CIN. Stepwise logistic regression methods showed that tumor size 5 cm (OR 7.81, 95% CI 2.99-20.46, p 0.001) and serum albumin [OR 0.29 (per 1 g/dl increase), 95% CI 0.11-0.75, p = 0.01] were risk factors of CIN.In this study, HCC tumor size and lower serum albumin level were independent predictors of CIN after TACE. |
| تدمد: | 1437-7799 1342-1751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6f27dea051af69f8c856f8d480f9be https://doi.org/10.1007/s10157-019-01751-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....1e6f27dea051af69f8c856f8d480f9be |
| قاعدة البيانات: | OpenAIRE |
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