In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy
العنوان: | In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy |
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المؤلفون: | Konrad J. Werhahn, Erwan Dupont, Mathias Schreckenberger, Hans-Georg Buchholz, Andreas Fellgiebel, Christian Landvogt, Julia Tillmanns, Heiko J. Luhmann, Peter Bartenstein, Paul Cumming, Heidrun Potschka, Axel Heimann, Fabian Debus, Igor Yakushev |
المصدر: | Epilepsia. 51:415-422 |
بيانات النشر: | Wiley, 2010. |
سنة النشر: | 2010 |
مصطلحات موضوعية: | Male, Pyrrolidines, Dopamine, Receptors, Dopamine, Temporal lobe, Epilepsy, Neuroimaging, In vivo, Animals, Humans, Medicine, Brain Mapping, Receptors, Dopamine D2, business.industry, Pilocarpine, Receptors, Dopamine D3, Brain, medicine.disease, Corpus Striatum, Rats, Disease Models, Animal, Epilepsy, Temporal Lobe, Neurology, Dopamine receptor, Positron-Emission Tomography, Benzamides, Autoradiography, Neurology (clinical), business, Neuroscience, Preclinical imaging, Ex vivo, medicine.drug |
الوصف: | Alterations in dopamine neurotransmission in animal models of epilepsies have been frequently demonstrated using invasive neuroscience or ex vivo techniques. We aimed to test whether corresponding alterations could be detected by noninvasive in vivo brain imaging with positron emission tomography (PET) in the chronic phase of the rat pilocarpine model of temporal lobe epilepsy.Six pilocarpine-treated Wistar rats exhibiting spontaneous recurrent seizures and nine control rats were studied with PET using [(18)F]-fallypride, a high-affinity dopamine D(2/3) receptor ligand. Parametric images of [(18)F]-fallypride specific binding were calculated using a reference tissue method, and the two groups were contrasted by whole-brain voxel-based analysis implemented in statistical parametric mapping (SPM5).Dopamine D(2/3) receptor availability was 27% lower in the bilateral anterior caudate-putamen of pilocarpine-treated rats as compared to controls (p0.05), but binding was unaffected in other striatal or extrastriatal regions.The finding of substantially reduced availability of dopamine D(2/3) receptors in the anterior caudate-putamen of rats during the chronic phase of the pilocarpine model is in agreement with results of invasive (microinjection, microdialysis) animal studies that have revealed increased dopamine tonus and a D(2/3) receptor-mediated anticonvulsant action of dopamine in the anterior segment of the rat striatum. The present PET approach could be prospectively applied for monitoring dopamine receptor changes longitudinally, that is, at different phases of the epileptogenic process, and opens perspectives for testing dopaminergic agents as potential antiepileptogenic drugs. |
تدمد: | 1528-1167 0013-9580 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeb4a8bb08dfe5741cf85e369d8eb73 https://doi.org/10.1111/j.1528-1167.2009.02272.x |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....1eeb4a8bb08dfe5741cf85e369d8eb73 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15281167 00139580 |
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