Curvature-induced cell rearrangements in biological tissues
العنوان: | Curvature-induced cell rearrangements in biological tissues |
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المؤلفون: | Yuting Lou, Jean-Francois Rupprecht, Tetsuya Hiraiwa, Timothy Saunders |
المساهمون: | Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), CPT - E5 Physique statistique et systèmes complexes, Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS) |
بيانات النشر: | HAL CCSD, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | [PHYS]Physics [physics], [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] |
الوصف: | On a curved surface, epithelial cells can adapt to geometric constraints by tilting and by exchanging their neighbors from apical to basal sides, known as an apicobasal T1 (AB-T1) transition. The relationship between cell tilt, AB-T1 transitions, and tissue curvature still lacks a unified understanding. Here, we propose a general framework for cell packing in curved environments and explain the formation of AB-T1 transitions under different conditions. We find that steep curvature gradients can lead to cell tilting and induce AB-T1 transitions. Conversely, large curvature anisotropy can drive AB-T1 transitions by hydrostatic pressure. The two mechanisms compete to determine the impact of tissue geometry and mechanics on optimized cell rearrangements in 3D. |
اللغة: | English |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200c207f3c9bf0ac25fd9c2192b97167 https://hal.science/hal-03820121 |
رقم الأكسشن: | edsair.doi.dedup.....200c207f3c9bf0ac25fd9c2192b97167 |
قاعدة البيانات: | OpenAIRE |
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