Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma
| العنوان: | Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma |
|---|---|
| المؤلفون: | Jack L Williams, Chris Smith, Charlotte Hall, Zakaa Khaled, Avinaash Maharaj, Ruth Kwong, James Pittaway, Josefina Casas, Laila Parvanta, Tarek Ezzat Abdel-Aziz, Fausto Palazzo, Teng-Teng Chung, Leonardo Guasti, Lou Metherell, Rathi Prasad |
| المصدر: | European Journal of Endocrinology. 188 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Adrenocortical carcinoma, Sphingolipids, Endocrinology, Endocrinology, Diabetes and Metabolism, SGPL1, General Medicine, Sphingosine-1-phosphate lyase |
| الوصف: | Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes. Loss-of-function mutations in sphingosine-1-phosphate lyase (SGPL1) cause primary adrenal insufficiency and as a key degradative enzyme in the sphingolipid pathway, SGPL1 also influences the balance of pro-proliferative and pro-apoptotic sphingolipids. We, therefore, hypothesized increased SGPL1 may be linked to increased disease severity in ACC. This work was supported by Barts Charity grants MGU0361 to L.M. and R.P.; MGU0438 to L.M.; MGU0528 to R.K.; MGU0436 to L.G.; Government of Trinidad and Tobago Research Fellowship to A.M.; Medical Research Council (MRC) UK Clinical Academic Research Partner grant (MR/T02402X/1) to R.P. and MRC clinical research fellowships (MR/S022155/1) to J.P. and (MR/W015935/1) to R.K. |
| تدمد: | 1479-683X 0804-4643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206764cc8f83217005eb62131418d1fd https://doi.org/10.1093/ejendo/lvac007 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....206764cc8f83217005eb62131418d1fd |
| قاعدة البيانات: | OpenAIRE |
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