The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma
| العنوان: | The Clinical Significance of Cancer Stem Cell Markers ALDH1A1 and CD133 in Lung Adenocarcinoma |
|---|---|
| المؤلفون: | Tsunehiro Oyama, Daigo Kawano, Takashi Yoshimatsu, Tetsuya So, Naoki Yamashita, Takeaki Miyata, Hanae Higa, Atsushi Sekimura, Akinobu Gotoh |
| المصدر: | Anticancer research. 37(5) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Multivariate analysis, Lung Neoplasms, Adenocarcinoma of Lung, Kaplan-Meier Estimate, Adenocarcinoma, Aldehyde Dehydrogenase 1 Family, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Cancer stem cell, Recurrence, Internal medicine, medicine, Biomarkers, Tumor, Humans, Clinical significance, AC133 Antigen, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Lung, biology, Hazard ratio, Retinal Dehydrogenase, General Medicine, Aldehyde Dehydrogenase, Middle Aged, medicine.disease, Prognosis, ALDH1A1, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, biology.protein, Neoplastic Stem Cells, Immunohistochemistry, Female |
| الوصف: | Background/Aim: Aldehyde dehydrogenase-1A1 (ALDH1A1) and CD133 have been identified as markers of cancer stem cells (CSCs). We investigated the expression of these markers and their clinical significance in lung adenocarcinoma. Materials and Methods: An immunohistochemical analysis of ALDH1A1 and CD133 expression of 92 lung adenocarcinomas was performed. The association between the expression of both markers and cancer-related death and recurrence was determined. Results: Cancer-related death and tumor recurrence were observed in 15 and 17 cases, respectively. The expression of CD133, but not ALDHA1A, was significantly associated with poorer overall survival (p |
| تدمد: | 1791-7530 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cd2ad0b17917ce8f6d545276cade69 https://pubmed.ncbi.nlm.nih.gov/28476825 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....22cd2ad0b17917ce8f6d545276cade69 |
| قاعدة البيانات: | OpenAIRE |
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