Genetic and epigenetic features in radiation sensitivity
| العنوان: | Genetic and epigenetic features in radiation sensitivity |
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| المؤلفون: | Maria R Perez, Michel H. Bourguignon, P. Gisone, Edgardo D. Carosella, Diana Dubner, Marina Di Giorgio, Severino Michelin |
| المصدر: | European Journal of Nuclear Medicine and Molecular Imaging. 32:351-368 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Population, Radiation Tolerance, Risk Assessment, Epigenesis, Genetic, Ionizing radiation, Radiation Protection, Radiation sensitivity, Risk Factors, Radiation, Ionizing, medicine, Humans, Genetic Predisposition to Disease, Radiology, Nuclear Medicine and imaging, Medical physics, Practice Patterns, Physicians', Radiation Injuries, education, Intensive care medicine, Genetic testing, education.field_of_study, medicine.diagnostic_test, business.industry, Radiation Therapist, Genetic Diseases, Inborn, Cancer, General Medicine, medicine.disease, Radiation therapy, Practice Guidelines as Topic, Radiation protection, business |
| الوصف: | Recent progress especially in the field of gene identification and expression has attracted greater attention to the genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. This issue is especially important for radiation therapists since hypersensitive patients may suffer from adverse effects in normal tissues following standard radiation therapy, while normally sensitive patients could receive higher doses of radiation, offering a better likelihood of cure for malignant tumours. Although only a small percentage of individuals are "hypersensitive" to radiation effects, all medical specialists using ionising radiation should be aware of the aforementioned progress in medical knowledge. The present paper, the second of two parts, reviews human disorders known or strongly suspected to be associated with hypersensitivity to ionising radiation. The main tests capable of detecting such pathologies in advance are analysed, and ethical issues regarding genetic testing are considered. The implications for radiation protection of possible hypersensitivity to radiation in a part of the population are discussed, and some guidelines for nuclear medicine professionals are proposed. |
| تدمد: | 1619-7089 1619-7070 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2510663ae2a14227bebbdd8309b40987 https://doi.org/10.1007/s00259-004-1731-6 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2510663ae2a14227bebbdd8309b40987 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16197089 16197070 |
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