Cutaneous metastases of pancreatic neuroendocrine carcinoma
| العنوان: | Cutaneous metastases of pancreatic neuroendocrine carcinoma |
|---|---|
| المؤلفون: | Lina Naga, Anthony A. Gaspari, Mary E. Laschinger |
| المصدر: | Giornale Italiano di Dermatologia e Venereologia. 153 |
| بيانات النشر: | Edizioni Minerva Medica, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, Skin Neoplasms, Keratin-20, Dermatology, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, Humans, Medicine, Neuroendocrine carcinoma, Aged, business.industry, Merkel cell carcinoma, Pancreatic Neuroendocrine Carcinoma, medicine.disease, Primary tumor, digestive system diseases, Carcinoma, Neuroendocrine, Neuroendocrine Carcinomas, Carcinoma, Merkel Cell, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, business |
| الوصف: | Neuroendocrine carcinomas with distant metastases are rarely reported in the literature, with cutaneous metastases being among the most infrequently reported sites. The importance of distinguishing metastatic neuroendocrine carcinoma (NEC) from primary neuroendocrine carcinoma in the skin, or Merkel cell carcinoma (MCC), has been stressed in the literature, with CK20 positivity traditionally being reported as the key diagnostic feature of MCC. Our case not only serves as one of the few reported cases of cutaneous metastases of a visceral NEC, but also serves to caution providers as to the use of CK20 positivity as an absolute diagnostic feature. We present a case of a 67-year-old female with widespread cutaneous metastases of a pancreatic NEC. Immunohistochemical staining revealed CK20 positivity, despite visceral origin of the primary tumor. This case serves to highlight not only a rare presentation of cutaneous metastases of a pancreatic neuroendocrine carcinoma, which has yet to be reported in the literature, but also serves as the only report of a pancreatic NEC with CK20 positivity, providing evidence for cautionary use of CK20 staining for diagnostic purposes, particularly for visceral NECs which have been under-represented in the literature. |
| تدمد: | 1827-1820 0392-0488 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2564c1c2e07faf8dde4a3daa6b361f7c https://doi.org/10.23736/s0392-0488.17.05103-3 |
| رقم الأكسشن: | edsair.doi.dedup.....2564c1c2e07faf8dde4a3daa6b361f7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18271820 03920488 |
|---|