State of the Art in Respiratory Syncytial Virus Drug Discovery and Development
| العنوان: | State of the Art in Respiratory Syncytial Virus Drug Discovery and Development |
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| المؤلفون: | Neil Mathews, G. Stuart Cockerill, James A. D. Good |
| المصدر: | Journal of Medicinal Chemistry. 62:3206-3227 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Palivizumab, viruses, Respiratory Syncytial Virus Infections, Antiviral Agents, 01 natural sciences, Viral infection, Virus, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Viral life cycle, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Drug discovery, Ribavirin, Treatment options, Nucleocapsid Proteins, Virology, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Respiratory Syncytial Virus, Human, Molecular Medicine, Viral Fusion Proteins, Direct acting, medicine.drug |
| الوصف: | Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment options have been limited to palivizumab, a monoclonal antibody, approved for prophylaxis in high-risk infants and ribavirin with very limited efficacy and significant safety concerns. This Perspective surveys the range of direct acting antiviral agents (DAAs) that target key steps in the viral life cycle. A number of approaches to DAAs have produced landmark clinical studies over the past few years, notably in fusion and nucleoside inhibitors, and an update of the clinical status of these compounds is provided. Non-nucleoside inhibitors of replication are reviewed in addition to inhibitors of other mechanisms, notably the RSV N and G proteins. This article will provide an informative perspective of the current status of drug discovery targeted at providing an effective therapy for RSV infection. |
| تدمد: | 1520-4804 0022-2623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25717f131d07d995c1fbd86b51c04e85 https://doi.org/10.1021/acs.jmedchem.8b01361 |
| رقم الأكسشن: | edsair.doi.dedup.....25717f131d07d995c1fbd86b51c04e85 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204804 00222623 |
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