Association analysis of genetic variants in the ghrelin and tumor necrosis factor α genes and the risk for non-Hodgkin’s lymphoma in Kuwaitis
| العنوان: | Association analysis of genetic variants in the ghrelin and tumor necrosis factor α genes and the risk for non-Hodgkin’s lymphoma in Kuwaitis |
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| المؤلفون: | Maryam H. Alrashid, Suzanne A. Al-Bustan, Salem H. Alshemmari, Jeethu Anu Geo, Ahmad Al-Serri |
| المصدر: | Cancer Biomarkers |
| بيانات النشر: | IOS Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Pharmacogenomic Variants, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Risk Factors, Internal medicine, hemic and lymphatic diseases, Genetics, Genetic predisposition, medicine, GHRL, SNP, Humans, Genetic Predisposition to Disease, Genotyping, Genetic association, business.industry, Tumor Necrosis Factor-alpha, Lymphoma, Non-Hodgkin, General Medicine, Middle Aged, medicine.disease, non-Hodgkin’s lymphoma, Obesity, Ghrelin, Lymphoma, Non-Hodgkin's lymphoma, 030104 developmental biology, Kuwait, 030220 oncology & carcinogenesis, TNF-α, Case-Control Studies, business, Research Article, SNPs |
| الوصف: | BACKGROUND: Non-Hodgkin’s lymphoma (NHL) is the most common hematological malignancy in the world. Many etiologic factors have been implicated in the risk of developing NHL, including genetic susceptibility and obesity. Single-nucleotide polymorphisms (SNPs) in Ghrelin (GHRL), an anti-inflammatory hormone, and tumor necrosis factor α (TNF-α), an inflammatory cytokine, have been independently associated with the risk for obesity and NHL. OBJECTIVE: To investigate the association between SNPs in GHRL and TNF-α and the risk for NHL and obesity in Kuwaitis. METHODS: We recruited 154 Kuwaiti NHL patients and 217 controls. Genotyping was performed for rs1629816 (GHRL promoter region), rs35684 (GHRL 3’ untranslated region), and rs1800629 (TNF-α promoter region). Logistic regression analysis was performed to assess the association of the investigated SNPs with NHL and the relationship between the selected SNPs with BMI in each group separately. RESULTS: We show that rs1629816 GG was associated with an increased risk for NHL in our sample (p= 0.0003, OR 1.82; CI: 1.31–2.54). None of the investigated SNPs were associated with obesity, nor was obesity found to be associated with the risk for NHL. CONCLUSIONS: Our study demonstrates an association between rs1629816, a SNP in the GHRL regulatory region, and NHL in Kuwaitis. |
| اللغة: | English |
| تدمد: | 1875-8592 1574-0153 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0d8342b9439d0d5dfd35347ad3cfc6 http://europepmc.org/articles/PMC8461683 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....2c0d8342b9439d0d5dfd35347ad3cfc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758592 15740153 |
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