Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer
| العنوان: | Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer |
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| المؤلفون: | Miguel A Mendoza-Catalán, Berenice Illades-Aguiar, Eric Genaro Salmerón-Bárcenas, Luz del Carmen Alarcón-Romero, Ana E Zacapala-Gómez, Francisco I Torres-Rojas, Ma Isabel Zubillaga-Guerrero |
| المصدر: | Biomarkers in Medicine. 14:1461-1471 |
| بيانات النشر: | Future Medicine Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Integrins, Protein subunit, Clinical Biochemistry, Immunocytochemistry, Integrin, Gene Expression, Uterine Cervical Neoplasms, In situ hybridization, Alphapapillomavirus, 03 medical and health sciences, 0302 clinical medicine, Laminin, Drug Discovery, Biomarkers, Tumor, Humans, Medicine, Mexico, Genotyping, In Situ Hybridization, biology, business.industry, Integrin beta1, Papillomavirus Infections, Biochemistry (medical), Middle Aged, Prognosis, Immunohistochemistry, Molecular biology, Gene Expression Regulation, Neoplastic, Exact test, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, biology.protein, Female, business |
| الوصف: | Aim: The aim of this study was to analyze the prognostic value of integrin subunit β1 and laminin γ1 chain in patients with cervical cancer (CC). Materials & methods: The study included 96 samples. Cytological diagnosis, human papillomavirus (HPV) genotyping, HPV integration status and integrin subunit β1 and laminin γ1 chain expressions were performed or determined using Papanicolaou smear, INNO-LiPA® Genotyping Extra Kit, in situ hybridization, and immunocytochemistry, respectively. The association between variables was calculated using chi-squared and Fisher’s exact test; logistic regression analysis was performed to calculate odds ratios and CI at 95%. Results: Our results show that integrin subunit β1 and laminin γ1 chain expressions increase according to tumor progression. Integrin subunit β1 and laminin γ1 chain expressions are associated with cytological diagnosis (p |
| تدمد: | 1752-0371 1752-0363 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0213e772e680666de0765fb2721280 https://doi.org/10.2217/bmm-2020-0140 |
| رقم الأكسشن: | edsair.doi.dedup.....2d0213e772e680666de0765fb2721280 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17520371 17520363 |
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