A comparative optical coherence tomography study in neuromyelitis optica spectrum disorder and multiple sclerosis
| العنوان: | A comparative optical coherence tomography study in neuromyelitis optica spectrum disorder and multiple sclerosis |
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| المؤلفون: | Bilal Majed, Olivier Outteryck, Hélène Zéphir, S. Defoort-Dhellemmes, Patrick Vermersch |
| المصدر: | Multiple Sclerosis Journal. 21:1781-1793 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Retinal Ganglion Cells, medicine.medical_specialty, Multiple Sclerosis, Visual acuity, genetic structures, Population, Audiology, chemistry.chemical_compound, Optical coherence tomography, Ophthalmology, medicine, Humans, Optic neuritis, education, education.field_of_study, Neuromyelitis optica, Expanded Disability Status Scale, medicine.diagnostic_test, business.industry, Multiple sclerosis, Neuromyelitis Optica, Retinal, Middle Aged, medicine.disease, eye diseases, Neurology, chemistry, Female, sense organs, Neurology (clinical), Atrophy, medicine.symptom, business, Biomarkers, Tomography, Optical Coherence |
| الوصف: | Objectives: The aim of this study was to find, using spectral domain-optical coherence tomography (SD-OCT), retinal imaging biomarkers differentiating neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS) and healthy controls (HCs). Materials and methods: The population was composed of patients with NMOSD ( n=23) or MS ( n=110) and of HCs ( n=75). Evaluation criteria were retinal thickness/volume, visual acuity, low contrast vision acuity and Expanded Disability Status Scale score. Results: Considering all eyes and after statistical adjustments including the number of optic neuritis (ON) episodes, we found that NMOSD patients did not have significantly more retinal atrophy than MS patients; whereas MS non-optic neuritis (NON) eyes had thinner temporal ( p=0.032) and temporo-superior peripapillary retinal nerve fibre layer (pRNFL; p=0.011) thicknesses than NMOSD NON eyes; in addition, NMOSD NON eyes presented significant naso-inferior pRNFL ( p=0.024), temporal pRNFL ( p=0.039), macular ganglion cell complex ( p=0.004) and ganglion cell layer ( p=0.002) atrophy vs HC eyes. We identified significant correlations between visual and clinical disability and retinal thicknesses in both diseases. Conclusion: OCT may help to differentiate NMOSD and MS by focusing on the NON eyes (temporal pRNFL atrophy more severe in MS). Moreover, we discuss the possibility of a retinal degenerative process independent of ON in NMOSD. |
| تدمد: | 1477-0970 1352-4585 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eeb621ea7a223f12ed744cc067b3ba0 https://doi.org/10.1177/1352458515578888 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....2eeb621ea7a223f12ed744cc067b3ba0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770970 13524585 |
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