Iron Redox Chemistry and Implications in the Parkinson's Disease Brain
| العنوان: | Iron Redox Chemistry and Implications in the Parkinson's Disease Brain |
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| المؤلفون: | Heather R. Lucas, Dinendra L Abeyawardhane |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) |
| بيانات النشر: | Hindawi, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Parkinson's disease, Dopamine, Iron, Substantia nigra, Disease, Oxidative phosphorylation, Review Article, Neurotransmission, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Amino Acid Sequence, lcsh:QH573-671, Chemistry, Pars compacta, lcsh:Cytology, Neurodegeneration, Dopaminergic, Brain, Parkinson Disease, Cell Biology, General Medicine, medicine.disease, 030104 developmental biology, alpha-Synuclein, Neuroscience, Oxidation-Reduction, 030217 neurology & neurosurgery |
| الوصف: | The etiology of Parkinson’s disease (PD) is linked with cellular inclusions in the substantia nigra pars compacta region of the brain that are enriched in the misfolded presynaptic protein α-synuclein (αS) and death of the dopaminergic neurons. Brain iron homeostasis governs both neurotransmission and neurodegeneration; hence, the role of iron in PD progression and neuronal health is apparent. Elevated iron deposits become prevalent in the cerebral region upon aging and even more so in the PD brain. Structural as well as oxidative modifications can result from coordination of αS with redox active iron, which could have functional and/or pathological implications. In this review, we will discuss iron-mediated αS aggregation, alterations in iron metabolism, and the role of the iron-dopamine couple. Moreover, iron interactions with N-terminally acetylated αS, the physiologically relevant form of the human protein, will be addressed to shed light on the current understanding of protein dynamics and the physiological environment in the disease state. Oxidative pathways and biochemical alterations resulting from aberrant iron-induced chemistry are the principal focus of this review in order to highlight the plethora of research that has uncovered this emerging dichotomy of iron playing both functional and disruptive roles in PD pathology. |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3163b99c2a0c5a120841f94d81b76963 http://europepmc.org/articles/PMC6803728 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3163b99c2a0c5a120841f94d81b76963 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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