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Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria

التفاصيل البيبلوغرافية
العنوان: Molecular typing of antibiotic-resistant Staphylococcus aureus in Nigeria
المؤلفون: FE Emele, Shylo E. Wardyn, Tara C. Smith, S. M. O'Malley, Ijeoma Emeka-Nwabunnia, Blake M. Hanson, A.K. Umeizudike, Francisca O. Nwaokorie, N. Idika, Rajeshwari Nair
المصدر: Journal of Infection and Public Health, Vol 8, Iss 2, Pp 187-193 (2015)
بيانات النشر: Elsevier BV, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Veterinary medicine, medicine.medical_specialty, Staphylococcus aureus, Penicillin binding proteins, Genotype, medicine.drug_class, Antibiotic resistance, Epidemiology, Bacterial Toxins, Antibiotics, Leukocidin, Exotoxins, Nigeria, Microbial Sensitivity Tests, Staphylococcal infections, medicine.disease_cause, Microbiology, lcsh:Infectious and parasitic diseases, Bacterial Proteins, Leukocidins, Drug Resistance, Bacterial, medicine, Humans, Penicillin-Binding Proteins, lcsh:RC109-216, mecA, Staphylococcal Protein A, business.industry, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, General Medicine, Staphylococcal Infections, biochemical phenomena, metabolism, and nutrition, medicine.disease, bacterial infections and mycoses, Anti-Bacterial Agents, spa typing, Molecular Typing, Phenotype, Infectious Diseases, PVL, business
الوصف: Summary: Background: Antibiotic-resistant Staphylococcus aureus including methicillin-resistant strains (MRSA) are a major concern in densely populated urban areas. Initial studies of S. aureus in Nigeria indicated existence of antibiotic-resistant S. aureus strains in clinical and community settings. Methods: 73 biological samples (40 throat, 23 nasal, 10 wound) were collected from patients and healthcare workers in three populations in Nigeria: Lagos University Teaching Hospital, Nigerian Institute of Medical Research, and Owerri General Hospital. Results: S. aureus was isolated from 38 of 73 samples (52%). Of the 38 S. aureus samples, 9 (24%) carried the Panton-Valentine leukocidin gene (PVL) while 16 (42%) possessed methicillin resistance genes (mecA). Antibiotic susceptibility profiles indicated resistance to several broad-spectrum antibiotics. Conclusion: Antibiotic-resistant S. aureus isolates were recovered from clinical and community settings in Nigeria. Insight about S. aureus in Nigeria may be used to improve antibiotic prescription methods and minimize the spread of antibiotic-resistant organisms in highly populated urban communities similar to Lagos, Nigeria. Keywords: Antibiotic resistance, Staphylococcus aureus, Nigeria, Epidemiology, spa typing, PVL, mecA
تدمد: 1876-0341
DOI: 10.1016/j.jiph.2014.08.001
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b6c3b762218b6441829ed0b00c9b18
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....32b6c3b762218b6441829ed0b00c9b18
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18760341
DOI:10.1016/j.jiph.2014.08.001