Mal de Meleda is an hereditary palmoplantar keratoderma named after Mljet Island in Croatia. The lives of those affected by this disease represent a complex situation that encompasses members of a vulnerable group. They require enlightenment and should be approached with awareness, taking into account their overall psychophysical status and the environment of each patient. Those afflicted with the Mal de Meleda have to deal with not only a difficult life due to their affliction, but they must also cope with the hardships of socialization while trying to realize a normal life within their island community. This is compounded by the frequent interviews and examinations of researchers interested in the various aspects of their illness. The subject of this paper is not about the nature of this disease, rather about the traces it has left on the (sub)consciousness of the population. It is also concerned with exploring ways of how to access patients and understanding the depth of their vulnerability. We shall present some thoughts tied to the interpersonal experiences of researchers and patients afflicted with Mal de Meleda.