The Role of Oxidative Stress in Intervertebral Disc Degeneration
| العنوان: | The Role of Oxidative Stress in Intervertebral Disc Degeneration |
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| المؤلفون: | Guoshuai Cao, Sidong Yang, Jianye Cao, Zixuan Tan, Linyu Wu, Fang Dong, Wenyuan Ding, Feng Zhang |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2022 (2022) Oxidative Medicine and Cellular Longevity |
| بيانات النشر: | Hindawi Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Aging, Disease Models, Animal, Oxidative Stress, QH573-671, Animals, Humans, Cell Biology, General Medicine, Intervertebral Disc Degeneration, Review Article, Cytology, Biochemistry, Rats |
| الوصف: | Intervertebral disc degeneration is a very common type of degenerative disease causing severe socioeconomic impact, as well as a major cause of discogenic low back pain and herniated discs, placing a heavy burden on patients and the clinicians who treat them. IDD is known to be associating with a complex process involving in extracellular matrix and cellular damage, and in recent years, there is increasing evidence that oxidative stress is an important activation mechanism of IDD and that reactive oxygen and reactive nitrogen species regulate matrix metabolism, proinflammatory phenotype, autophagy and senescence in intervertebral disc cells, apoptosis, autophagy, and senescence. Despite the tremendous efforts of researchers within the field of IDD pathogenesis, the proven strategies to prevent and treat this disease are still very limited. Up to now, several antioxidants have been proved to be effective for alleviating IDD. In this article, we discussed that oxidative stress accelerates disc degeneration by influencing aging, inflammation, autophagy, and DNA methylation, and summarize some antioxidant therapeutic measures for IDD, indicating that antioxidant therapy for disc degeneration holds excellent promise. |
| اللغة: | English |
| تدمد: | 1942-0994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3439d8b3951a441528b15dd37e884284 https://doaj.org/article/bd2725a22e094f19bcc15ef08be48165 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....3439d8b3951a441528b15dd37e884284 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 |
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